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Effects of ACE Inhibition on Cyclosporine A-Induced Hypertension and Nephrotoxicity in Spontaneously Hypertensive Rats on a High-sodium Diet

Cyclosporine A (CsA)-induced hypertension has been shown to be dependent on the level of dietary salt. The present study assessed the role of the renin-angiotensin system in the development of CsA-induced hypertension and nephrotoxicity in spontaneously hypertensive rats (SHR) on a high-sodium diet....

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Bibliographic Details
Published in:Blood pressure 1999, Vol.8 (1), p.49-56
Main Author: EERO MERVAALA, MARKUS LASSILA, TIMO VASKONEN, LEENA KROGERUS, TUULA LÄHTEENMÄKI, HEIKKI VAPAATALO, HEIKKI KARPPANEN
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Language:English
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Summary:Cyclosporine A (CsA)-induced hypertension has been shown to be dependent on the level of dietary salt. The present study assessed the role of the renin-angiotensin system in the development of CsA-induced hypertension and nephrotoxicity in spontaneously hypertensive rats (SHR) on a high-sodium diet. In addition, we examined whether ACE inhibition prevents the detrimental effects of CsA on blood pressure, kidney function and vascular morphology in SHR on high sodium intake. Eight-week-old SHR were divided into three different groups (n
ISSN:0803-7051
1651-1999
DOI:10.1080/080370599438392