Clinical Value of a Bispecific Antibody Binding to Thyroglobulin and Thyroperoxidase (TGPO-aAb) in Various Thyroid Diseases

TGPO-aAb is a bispecific antibody which binds to thyroglobulin as well as thyroid peroxidase. It is supposed to be raised in some patients with autoimmune thyroid disease. We investigated 205 patients suffering from Graves' disease (n = 81), Hashimoto's thyroiditis (n = 36), toxic nodular...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 1999-01, Vol.29 (4), p.257-262
Main Authors: Zöphel, Klaus, Grüning, Thomas, Wunderlich, Gerd, Franke, Wolf-Gunter
Format: Article
Language:English
Subjects:
Adult
Antibodies, Bispecific - immunology
Antibody Specificity
Autoantibodies
Autoantibodies - immunology
Biological and medical sciences
Endocrinopathies
Hashimoto's thyroiditis
Humans
Iodide Peroxidase - immunology
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
TGPO
Thyroglobulin
Thyroglobulin - immunology
Thyroid Diseases - immunology
Thyroid. Thyroid axis (diseases)
Thyroperoxidase
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Summary:TGPO-aAb is a bispecific antibody which binds to thyroglobulin as well as thyroid peroxidase. It is supposed to be raised in some patients with autoimmune thyroid disease. We investigated 205 patients suffering from Graves' disease (n = 81), Hashimoto's thyroiditis (n = 36), toxic nodular goitre (n = SO), differentiated carcinoma of the thyroid (n = 10), and autoimmune thyropathy of unknown origin (n = 28). An immunoradiometric assay was used to measure serum TGPO-aAb. Eighty-nine of 205 patients had elevated titres of TGPO-aAb. If TGPO-aAb were raised then autoantibodies against thyroglobulin and thyroid peroxidase were always raised, too. This was, however, not true vice versa. We found TGPO-aAb in 61% of patients with Hashimoto's, 49% of patients with Graves', 64% of patients with autoimmune thyropathy, but only in 12% of patients with toxic nodular goitre. In patients with thyroid carcinoma TGPO-aAb was found only if there was evidence of paraneoplastic autoimmune thyroiditis. We re-examined 16 of 36 patients with Hashimoto's thyroiditis after 1 year: 8 patients had retained their raised TGPO-aAb, 4 patients showed no TGPO-aAb on both occasions, and 4 patients had 'lost' their previously raised TGPO-aAb on follow-up. We conclude that TGPO-aAb may provide additional information in Hashimoto's thyroiditis. Determination of TGPO-aAb does not allow to distinguish between various forms of autoimmune thyroid disease. Nevertheless, the presence of TC PO-a Ab and its variation during the natural course of autoimmune thyroid disease remains to be understood which would give a better insight into its clinical significance.
ISSN:0891-6934
1607-842X
DOI:10.3109/08916939908994744