A General Model for Genetic Recombination

A general model is proposed for genetic recombination. Its essential new feature is the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-strand (or symmetric) exchange. The likelihood of this transition from asymmetr...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1975-01, Vol.72 (1), p.358-361
Main Authors: Meselson, Matthew S., Radding, Charles M.
Format: Article
Language:English
Subjects:
Chromatids
Chromatids - metabolism
DNA
DNA - metabolism
DNA, Single-Stranded - metabolism
Genetic recombination
Isomerization
Mathematics
Medical genetics
Meiosis
Models, Biological
Molecular genetics
Molecular rotation
Molecular structure
Molecules
Nucleic Acid Conformation
Nucleic acid heteroduplexes
Recombination, Genetic
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Summary:A general model is proposed for genetic recombination. Its essential new feature is the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-strand (or symmetric) exchange. The likelihood of this transition from asymmetric to symmetric strand exchange determines certain characteristic features of recombination in any particular organism.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.72.1.358