Intraventricular Neurocytoma with Prominent Myelin Figures

A case is reported of inraventricular neurocytoma that had characteristic light microscopic findings of neurocytoma with prominent intracytoplasmic concentric lamellar structures mimicking myelin sheaths. On routine H & E-stained sections, this tumor showed intracytoplasmic vesicular bleb-like s...

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Bibliographic Details
Published in:Ultrastructural pathology 1999, Vol.23 (5), p.311-317
Main Authors: Park, S H, Ostrzega, N, Akers, M A, Vinters, H V
Format: Article
Language:English
Subjects:
Adolescent
Brain - diagnostic imaging
Cerebral Ventricle Neoplasms - diagnostic imaging
Cerebral Ventricle Neoplasms - surgery
Cerebral Ventricle Neoplasms - ultrastructure
Concentric Lamellar Structures
Electron Microscopy
Neurocytoma
Endoplasmic Reticulum, Smooth - ultrastructure
Female
Humans
Myelin Sheath - ultrastructure
Neurocytoma - diagnostic imaging
Neurocytoma - surgery
Neurocytoma - ultrastructure
Septum Pellucidum - pathology
Tomography, X-Ray Computed
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Summary:A case is reported of inraventricular neurocytoma that had characteristic light microscopic findings of neurocytoma with prominent intracytoplasmic concentric lamellar structures mimicking myelin sheaths. On routine H & E-stained sections, this tumor showed intracytoplasmic vesicular bleb-like structures having eosinophilic cores that were consistent with ultrastructural concentric lamellar structures. Immunohistochemically, this tumor was immunoreactive for synaptophysin and neurofilament, but negative for antibody to glial fibriallary acidic protein. Electron microscopic findings fulfilled the criteria for neurocytoma, with the presence of neurosecretory granules and neurotubules. These findings may suggest dual differentiation of this tumor into neurocytes and oligodendrocytes.
ISSN:0191-3123
1521-0758
DOI:10.1080/019131299281455