Endothelin-1 induced bronchial hyperresponsiveness in the rabbit: an ET(A) receptor-mediated phenomenon

• Published in: Naunyn-Schmiedeberg's archives of pharmacology 1999-12, Vol.360 (6), p.665
• Main Authors: D'Agostino, B, Gallelli, L, Falciani, M, Di Pierro, P, Rossi, F, Filippelli, A
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Airway Resistance - drug effects; Animals; Antihypertensive Agents - administration & dosage; Azepines - administration & dosage; Bosentan; Bronchi - drug effects; Bronchi - metabolism; Bronchoconstriction - drug effects; Bronchoconstriction - physiology; Endothelin Receptor Antagonists; Endothelin-1 - administration & dosage; Endothelin-1 - metabolism; Female; Histamine; Indoles - administration & dosage; Male; Muscle, Smooth - drug effects; Muscle, Smooth - metabolism; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin - agonists; Receptors, Endothelin - metabolism; Respiratory Hypersensitivity - chemically induced; Respiratory Hypersensitivity - diagnosis; Respiratory Hypersensitivity - physiopathology; Sulfonamides - administration & dosage; Vasoconstrictor Agents - administration & dosage; Viper Venoms - administration & dosage
• ISSN: 0028-1298
• DOI: 10.1007/s002109900146

Endothelin-1 (ET-1) is a potent and efficacious spasmogen of airway smooth muscle. Recent observations suggest that an increased intrapulmonary production of ET-1 may occur in asthma. Our previous study showed that endothelin-1 induced bronchial hyperresponsiveness to inhaled histamine in the rabbit. The aim of this study was to investigate whether the ET(A) and ET(B) receptors mediate the bronchial hyperresponsiveness induced by endothelin-1 in the rabbit. Our data showed that bronchial hyperresponsiveness induced by ET-1 was significantly inhibited (P