Alcohol-acetaminophen syndrome: Even moderate social drinkers are at risk

Long-time alcohol users who take acetaminophen in therapeutic or modestly excessive doses are at risk for severe hepatic injury and possibly acute liver failure. Diagnosis may be difficult because presenting symptoms are vague. The authors review management of acetaminophen toxicity in both users an...

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Bibliographic Details
Published in:Postgraduate medicine 2000-01, Vol.107 (1), p.189-195
Main Authors: Draganov, Peter, Durrence, Hugh, Cox, Christopher, Reuben, Adrian
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - adverse effects
Acetaminophen - metabolism
Alcohol Drinking
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - adverse effects
Analgesics, Non-Narcotic - metabolism
Drug Interactions
Drug Overdose
Ethanol - metabolism
Humans
Liver Failure, Acute - chemically induced
Liver Failure, Acute - surgery
Liver Transplantation
Syndrome
Citations: Items that this one cites
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Description
Summary:Long-time alcohol users who take acetaminophen in therapeutic or modestly excessive doses are at risk for severe hepatic injury and possibly acute liver failure. Diagnosis may be difficult because presenting symptoms are vague. The authors review management of acetaminophen toxicity in both users and nonusers of alcohol and emphasize the need for greater awareness among healthcare providers and acetaminophen users of this preventable and treatable condition.
ISSN:0032-5481
1941-9260
DOI:10.3810/pgm.2000.01.831