Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults

• Published in: Scandinavian journal of clinical and laboratory investigation 1999, Vol.59 (8), p.587-592
• Main Authors: Vinge, E., Lindergård, B., Nilsson-Ehle, P., Grubb, A.
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Adolescent; Adult; Basic Medicine; Biological and medical sciences; Biomarkers - blood; Body Constitution; Clinical Medicine; Creatinine - blood; Cystatin C; Cystatins - blood; Farmakologi och toxikologi; Female; Glomerular Filtration Rate; Humans; Investigative techniques, diagnostic techniques (general aspects); Iohexol - pharmacokinetics; Klinisk medicin; Läkemedelskemi; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Medicinal Chemistry; Medicinska och farmaceutiska grundvetenskaper; Middle Aged; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Pharmacology and Toxicology; Regression Analysis; Sex characteristics; Urinary system; Urologi och njurmedicin; Urology and Nephrology
• ISSN: 0036-5513; 1502-7686; 1502-7686
• DOI: 10.1080/00365519950185076

In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual­energy X­ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p