Hormesis: interpreting the β-curve using control theory

Data from experiments exposing colonial hydroids to toxic growth inhibitors have provided evidence of growth control mechanisms that respond adaptively to counter toxic inhibition. Analysis of growth data and the development of simulation models provide an interpretation of both α‐ and β‐curves. The...

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Bibliographic Details
Published in:Journal of applied toxicology 2000-03, Vol.20 (2), p.93-101
Main Author: Stebbing, A. R. D.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Animals
Biological and medical sciences
Cnidaria - drug effects
Cnidaria - growth & development
Copper - toxicity
Dose-Response Relationship, Drug
General aspects. Methods
hormesis
low dose
Medical sciences
Models, Biological
stimulation
Systems Theory
Toxicology
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Summary:Data from experiments exposing colonial hydroids to toxic growth inhibitors have provided evidence of growth control mechanisms that respond adaptively to counter toxic inhibition. Analysis of growth data and the development of simulation models provide an interpretation of both α‐ and β‐curves. The hypothesis also suggests that hormesis is related to adaptation by growth control mechanisms that confer tolerance to subsequent exposure. Copyright © 2000 John Wiley & Sons, Ltd.
ISSN:0260-437X
1099-1263
DOI:10.1002/(SICI)1099-1263(200003/04)20:2<93::AID-JAT640>3.0.CO;2-7