Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils

To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N-nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2000-03, Vol.60 (6), p.1512
Main Authors: Shimizu, N, Ikehara, Y, Inada, K, Nakanishi, H, Tsukamoto, T, Nozaki, K, Kaminishi, M, Kuramoto, S, Sugiyama, A, Katsuyama, T, Tatematsu, M
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemically induced
Adenocarcinoma - pathology
Animals
Carcinogens - toxicity
Carcinoma, Signet Ring Cell - chemically induced
Carcinoma, Signet Ring Cell - pathology
Cocarcinogenesis
Gerbillinae
Helicobacter Infections - drug therapy
Helicobacter Infections - microbiology
Helicobacter Infections - physiopathology
Helicobacter pylori - drug effects
Male
Methylnitrosourea - toxicity
Pyloric Antrum - pathology
Stomach Neoplasms - chemically induced
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival Rate
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Summary:To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N-nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.
ISSN:0008-5472