Atherogenic Lipids and Endothelial Dysfunction: Mechanisms in the Genesis of Ischemic Syndromes

Atherogenic lipids, particularly oxidized low-density lipoprotein, are responsible for a wide range of cellular dysfunctions within the vessel wall. The effects on endothelial cells disrupt normal control of vasomotion, with a reduction of effective nitric oxide activity, the development of a procoa...

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Bibliographic Details
Published in:Annual review of medicine 2000-01, Vol.51 (1), p.149-167
Main Authors: Adams, Mark R, Kinlay, Scott, Blake, Gavin J, Orford, James L, Ganz, Peter, Selwyn, Andrew P
Format: Article
Language:English
Subjects:
Arteriosclerosis - complications
Arteriosclerosis - physiopathology
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cell Division
cholesterol
endothelium
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Humans
Ischemia - etiology
Lipoprotein(a) - physiology
Lipoproteins, LDL - physiology
Medical sciences
nitric oxide
Nitric Oxide - physiology
Triglycerides - physiology
Vasomotor System - physiopathology
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Summary:Atherogenic lipids, particularly oxidized low-density lipoprotein, are responsible for a wide range of cellular dysfunctions within the vessel wall. The effects on endothelial cells disrupt normal control of vasomotion, with a reduction of effective nitric oxide activity, the development of a procoagulant surface, chronic low-grade inflammation, and abnormal cell growth. These changes are central not only in the development of atherosclerosis but also in the evolution of both stable and unstable ischemic syndromes. There is growing evidence that these abnormal changes in cell function respond rapidly to changes in the atherogenic lipids. Certain cell functions can improve within hours or days of cholesterol lowering.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.51.1.149