Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent

• Published in: Journal of Virology 2000-06, Vol.74 (12), p.5432-5440
• Main Authors: Beringue, V, Adjou, K T, Lamoury, F, Maignien, T, Deslys, J P, Race, R, Dormont, D
• Format: Article
• Language: English
• Subjects: Amphotericin B - administration & dosage; Amphotericin B - analogs & derivatives; Amphotericin B - metabolism; Amphotericin B - pharmacology; Amphotericin B - therapeutic use; Animals; Brain - drug effects; Brain - metabolism; Brain - pathology; Congo red; Congo Red - administration & dosage; Congo Red - metabolism; Congo Red - pharmacology; Congo Red - therapeutic use; Cricetinae; Dextran Sulfate - administration & dosage; Dextran Sulfate - metabolism; Dextran Sulfate - pharmacology; Dextran Sulfate - therapeutic use; Dextran sulfate 500; Dose-Response Relationship, Drug; Endopeptidase K - metabolism; Female; Injections, Intraperitoneal; Kinetics; Life Sciences; Mice; Mice, Inbred C57BL; Mice, SCID; Microbiology and Parasitology; MS-8209; Organ Specificity; Pathogenesis and Immunity; Protein Binding; Protein Isoforms - administration & dosage; Protein Isoforms - antagonists & inhibitors; Protein Isoforms - isolation & purification; Protein Isoforms - metabolism; PrP protein; PrPSc Proteins - administration & dosage; PrPSc Proteins - antagonists & inhibitors; PrPSc Proteins - isolation & purification; PrPSc Proteins - metabolism; Scrapie - drug therapy; Scrapie - metabolism; Scrapie - pathology; Spleen - chemistry; Spleen - drug effects; Spleen - metabolism; Spleen - pathology; Time Factors
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.74.12.5432-5440.2000

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