Protective effect of benznidazole against parasite reactivation in patients chronically infected with Trypanosoma cruzi and treated with corticoids for associated diseases

Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with benznidazole, which was initiated at the same time of the use of corticoid in a group of 12 patients or 15 days afterwards in 6 patients. It has been proved in another pap...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 1999-09, Vol.32 (5), p.475
Main Authors: Rassi, A, Amato Neto, V, de Siqueira, A F, Ferriolli Filho, F, Amato, V S, Rassi Júnior, A
Format: Article
Language:Portuguese
Subjects:
Adolescent
Adult
Animals
Chagas Disease - complications
Chagas Disease - drug therapy
Chronic Disease
Female
Glucocorticoids - adverse effects
Glucocorticoids - pharmacology
Humans
Male
Middle Aged
Nitroimidazoles - therapeutic use
Trypanocidal Agents - therapeutic use
Trypanosoma - drug effects
Trypanosoma - growth & development
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Summary:Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with benznidazole, which was initiated at the same time of the use of corticoid in a group of 12 patients or 15 days afterwards in 6 patients. It has been proved in another paper that in the chronic phase of Chagas' disease corticoid use is associated with increased parasitemia, as evaluated by xenodiagnosis. In this study benznidazole use prevented this increase, and we suggest that in immunocompromised patients with chronic Chagas' disease the use of this drug could be useful.
ISSN:0037-8682