Specific treatment attempt, with ticlopidine, of patients with Chagas disease chronic phase

In a previous study, ticlopidine decreased the parasitemia and mortality of mice infected by Trypanosoma cruzi. Therefore, this drug was administered to 12 patients with Chagas' disease, in the chronic phase. For 90 days, 150, 200 or 250 mg were utilized according to whether the recipients were...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2000-03, Vol.33 (2), p.225
Main Authors: Rassi, A, Amato Neto, V, Rassi, G G, Ferriolli Filho, F, Amato, V S
Format: Article
Language:Portuguese
Subjects:
Adolescent
Adult
Chagas Disease - drug therapy
Child
Chronic Disease
Drug Evaluation
Female
Humans
Male
Ticlopidine - therapeutic use
Treatment Failure
Trypanocidal Agents - therapeutic use
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Summary:In a previous study, ticlopidine decreased the parasitemia and mortality of mice infected by Trypanosoma cruzi. Therefore, this drug was administered to 12 patients with Chagas' disease, in the chronic phase. For 90 days, 150, 200 or 250 mg were utilized according to whether the recipients were children, adolescents or adults, respectively. A fully unsuccessful outcome was documented, both serologically as well as parasitologically.
ISSN:0037-8682