4.0 T Water Proton T1 Relaxation Times in Normal Human Brain and During Acute Ethanol Intoxication

Background: It has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T1, anothe...

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Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2000-06, Vol.24 (6), p.830-836
Main Authors: Rooney, William D., Lee, Jing-Huei, Li, Xin, Wang, Gene-Jack, Franceschi, Dinko, Springer Jr, Charles S., Volkow, Nora D.
Format: Article
Language:English
Subjects:
Acute Alcohol Intoxication
Adult
Affect - drug effects
Alcoholic Intoxication - blood
Alcoholic Intoxication - metabolism
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Body Water - drug effects
Body Water - metabolism
Brain - drug effects
Brain - metabolism
Brain Water
Central Nervous System Depressants - pharmacology
Cognition - drug effects
Ethanol - pharmacology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Protons
T1 Relaxation Time
Toxicology
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Summary:Background: It has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T1, another possible explanation for reduced brain water proton T1 values is that the interaction between water and brain macromolecules is altered by ethanol. Methods: A 4.0 T magnetic resonance imaging (MRI) instrument was used to measure brain water proton T1 relaxation times before, during, and after ethanol intoxication (dose, 0.75 mg/kg) in healthy controls. Results: The T1 relaxation times as assessed with MRI were highly reproducible. The mean, paired ethanol‐induced differences in T1 were −0.004 ± 0.007 sec (mean ± standard deviation) for white matter and 0.010 ± 0.015 sec for internal gray matter structures, neither of which was significant. Conclusions: This reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects.
ISSN:0145-6008
1530-0277
DOI:10.1111/j.1530-0277.2000.tb02062.x