Thyroid status and response to endothelin-1 in rat arterial vessels

Departments of Kinesiology and Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 We have previously reported that changes in thyroid status are associated with significant alterations in skeletal muscle blood flow during exercise and that changes in endothelium-dependent vasod...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-08, Vol.279 (2), p.E252-E258
Main Authors: McAllister, Richard M, Luther, Kelli L, Pfeifer, P. Charles
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Aorta, Abdominal - drug effects
Aorta, Abdominal - metabolism
Citrate (si)-Synthase - metabolism
Dose-Response Relationship, Drug
Endothelin-1 - metabolism
Endothelin-1 - pharmacology
Hyperthyroidism - chemically induced
Hyperthyroidism - metabolism
Hypothyroidism - chemically induced
Hypothyroidism - metabolism
In Vitro Techniques
Male
Muscle, Skeletal - enzymology
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Nitroprusside - pharmacology
Norepinephrine - pharmacology
Propylthiouracil
Rats
Triiodothyronine
Vasoconstriction - drug effects
Vasoconstriction - physiology
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Departments of Kinesiology and Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 We have previously reported that changes in thyroid status are associated with significant alterations in skeletal muscle blood flow during exercise and that changes in endothelium-dependent vasodilation may contribute to these blood flow abnormalities. The purpose of this study was to test the hypothesis that altered endothelium-dependent vasoconstriction is also associated with changes in thyroid status. To test this hypothesis, rats were rendered hypothyroid with propylthiouracil (Hypo, n  = 14) or hyperthyroid with triiodothyronine (Hyper, n  = 14) over ~3 mo. Treatment efficacy was confirmed by altered ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.2000.279.2.E252