Effect of semisynthetic analog of alpha(1)-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein

Pseudo-alpha(1)-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of alpha(1)-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the semisynthet...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-05, Vol.129 (5), p.480
Main Authors: Pukhal'skii, A L, Shmarina, G V, Kalashnikova, E A, Shiyan, S D, Kokarovtseva, S N, Pukhal'skaya, D A, Bovin, N V
Format: Article
Language:English
Subjects:
Drug Interactions
Humans
Inflammation
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Orosomucoid - analogs & derivatives
Orosomucoid - immunology
Orosomucoid - pharmacology
Peptides - immunology
Peptides - pharmacology
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Summary:Pseudo-alpha(1)-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of alpha(1)-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the semisynthetic analog inhibited lymphocyte proliferation and stimulated the production of antiinflammatory cytokines by peripheral blood mononuclear leukocytes. However, it possessed no antioxidant activity and did not inhibit complement activation by the alternative pathway. The role of carbohydrate and protein components of alpha(1)-acid glycoprotein molecule in the realization of its biological effects is discussed.
ISSN:0007-4888
DOI:10.1007/BF02439809