A Test for the Diagnosis of Dead Regions in the Cochlea

• Published in: British journal of audiology 2000-08, Vol.34 (4), p.205-224
• Main Authors: Moore, B.C.J., Huss, M., Vickers, D. A., Glasberg, B. R., Alcántara, J.I.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Audiometry, Pure-Tone; Auditory Threshold - physiology; Biological and medical sciences; Cochlea - physiopathology; dead regions; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Hair Cells, Auditory, Inner - pathology; Hearing Aids; hearing loss; Hearing Loss, Sensorineural - diagnosis; Hearing Loss, Sensorineural - physiopathology; Hearing Loss, Sensorineural - rehabilitation; Humans; inner hair cells; Investigative techniques, diagnostic techniques (general aspects); masking; Medical sciences; Middle Aged; Noise - adverse effects; Non tumoral diseases; Otorhinolaryngology functional investigation (larynx, voice, audiometry, vestibular function, equilibration...); Otorhinolaryngology. Stomatology; Perceptual Masking; Psychophysics - methods; Severity of Illness Index
• ISSN: 0300-5364; 1471-2849
• DOI: 10.3109/03005364000000131

Abstract Hearing impairment may sometimes be associated with complete loss of inner hair cells (IHCs) over a certain region of the basilar membrane. We call this a 'dead region'. Amplification (using a hearing aid) over a frequency range corresponding to a dead region may not be beneficial and may even impair speech intelligibility. However, diagnosis of dead regions is not easily done from the audiogram. This paper reports the design and evaluation of a method for detecting and delimiting dead regions. A noise, called 'threshold equalizing noise' (TEN), was spectrally shaped so that, for normally hearing subjects, it would give equal masked thresholds for pure tone signals at all frequencies within the range 250-10 000 Hz. Its level is specified as the level in a one-ERB (132 Hz) wide band centred at 1000 Hz. Measurements obtained from 22 normal-hearing subjects and TEN levels of 30, 50 and 70 dB/ERB confirmed that the signal level at masked threshold was approximately equal to the noise level/ERB and was almost independent of signal frequency. Masked thresholds were measured for 20 ears of 14 subjects with sensorineural hearing loss, using TEN levels of 30, 50 and 70 dB/ERB. Psychophysical tuning curves (PTCs) were measured for the same subjects. When there are surviving IHCs corresponding to a frequency region with elevated absolute thresholds, a signal in that frequency region is detected via IHCs with characteristic frequencies (CFs) close to that region. In such a case, threshold in the TEN is close to that for normal-hearing listeners, provided that the noise intensity is sufficient to produce significant masking. Also, the tip of the PTC lies close to the signal frequency. When a dead region is present, the signal is detected via IHCs with CFs different from that of the signal frequency. In such a case, threshold in the TEN is markedly higher than normal, and the tip of the PTC is shifted away from the signal frequency. Generally, there was a very good correspondence between the results obtained using the TEN and the PTCs. We conclude that the measurement of masked thresholds in TEN provides a quick and simple method for the diagnosis of dead regions.