Oxidants and regulation of K+-Cl- cotransport in equine red blood cells

Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool L69 7ZJ, United Kingdom The effect of oxidants on K + -Cl cotransport (KCC) was investigated in equine red blood cells. Carbon monoxide mimicked O 2 . The substituted benzaldehyde, 12C79 (5 mM), markedly increased O 2...

Full description

Saved in:
Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2000-10, Vol.279 (4), p.C981-C989
Main Authors: Muzyamba, M. C, Speake, P. F, Gibson, J. S
Format: Article
Language:English
Subjects:
Animals
Benzaldehydes - pharmacology
Biological Transport, Active - drug effects
Carbon Monoxide - pharmacokinetics
Carbon Monoxide - pharmacology
Carrier Proteins - drug effects
Carrier Proteins - metabolism
Cell Size - drug effects
Dinitrochlorobenzene - pharmacology
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
Erythrocytes - cytology
Erythrocytes - drug effects
Erythrocytes - metabolism
Glutathione - metabolism
Horses
Hypotonic Solutions - pharmacology
Ion Transport - drug effects
K Cl- Cotransporters
Methemoglobin - metabolism
Nitrites - metabolism
Nitrites - pharmacology
Nitrogen - pharmacology
Osmolar Concentration
Oxidants - metabolism
Oxidants - pharmacology
Oxygen - metabolism
Phosphoprotein Phosphatases - antagonists & inhibitors
Potassium - metabolism
Symporters
Water - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool L69 7ZJ, United Kingdom The effect of oxidants on K + -Cl cotransport (KCC) was investigated in equine red blood cells. Carbon monoxide mimicked O 2 . The substituted benzaldehyde, 12C79 (5 mM), markedly increased O 2 affinity. In N 2 , however, O 2 saturation was low (
ISSN:0363-6143
1522-1563
DOI:10.1152/ajpcell.2000.279.4.c981