CYP1A1 I462V Genetic Polymorphism and Lung Cancer Risk in a Cohort of Men in Shanghai, China

Cytochrome P450 (CYP) CYP1A1 activates tobacco-related carcinogens. A point mutation at codon 462 in exon 7 of CYP1A1 results in a substitution of isoleucine by valine near the heme binding site. This mutation is rare in Caucasians but common in Japanese populations, in which association with increa...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-09, Vol.9 (9), p.987-991
Main Authors: LONDON, Stephanie J, YUAN, Jian-Min, COETZEE, Gerhard A, GAO, Yu-Tang, ROSS, Ronald K, YU, Mimi C
Format: Article
Language:English
Subjects:
Analysis. Health state
Benzo(a)pyrene - metabolism
Biological and medical sciences
Carcinogens - metabolism
China - epidemiology
Cohort Studies
Cytochrome P-450 Enzyme System - genetics
Epidemiology
General aspects
Glutathione Transferase - genetics
Humans
Inactivation, Metabolic
Logistic Models
Lung Neoplasms - enzymology
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Male
Medical sciences
Middle Aged
Odds Ratio
Pneumology
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Smoking - genetics
Smoking - metabolism
Tumors of the respiratory system and mediastinum
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Summary:Cytochrome P450 (CYP) CYP1A1 activates tobacco-related carcinogens. A point mutation at codon 462 in exon 7 of CYP1A1 results in a substitution of isoleucine by valine near the heme binding site. This mutation is rare in Caucasians but common in Japanese populations, in which association with increased risk of lung cancer has been reported. There are few data in other Asian populations. We investigated this I462V polymorphism using DNA from 214 incident cases of lung cancer and 669 controls in a prospective cohort study of 18,244 middle-aged and older men in Shanghai, China. The valine allele frequency was 0.138 among the control population. The I462V genotype was not appreciably associated with lung cancer risk overall. There was some suggestion that having at least one valine allele might be related to increased risk of lung cancer among smokers of
ISSN:1055-9965
1538-7755