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CYP1A1 I462V Genetic Polymorphism and Lung Cancer Risk in a Cohort of Men in Shanghai, China
Cytochrome P450 (CYP) CYP1A1 activates tobacco-related carcinogens. A point mutation at codon 462 in exon 7 of CYP1A1 results in a substitution of isoleucine by valine near the heme binding site. This mutation is rare in Caucasians but common in Japanese populations, in which association with increa...
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| Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-09, Vol.9 (9), p.987-991 |
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| container_end_page | 991 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | LONDON, Stephanie J YUAN, Jian-Min COETZEE, Gerhard A GAO, Yu-Tang ROSS, Ronald K YU, Mimi C |
| description | Cytochrome P450 (CYP) CYP1A1 activates tobacco-related
carcinogens. A point mutation at codon 462 in exon 7 of
CYP1A1 results in a substitution of isoleucine by valine
near the heme binding site. This mutation is rare in Caucasians but
common in Japanese populations, in which association with increased
risk of lung cancer has been reported. There are few data in other
Asian populations. We investigated this I462V polymorphism using DNA
from 214 incident cases of lung cancer and 669 controls in a
prospective cohort study of 18,244 middle-aged and older men in
Shanghai, China. The valine allele frequency was 0.138 among the
control population. The I462V genotype was not appreciably associated
with lung cancer risk overall. There was some suggestion that having at
least one valine allele might be related to increased risk of lung
cancer among smokers of |
| format | article |
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carcinogens. A point mutation at codon 462 in exon 7 of
CYP1A1 results in a substitution of isoleucine by valine
near the heme binding site. This mutation is rare in Caucasians but
common in Japanese populations, in which association with increased
risk of lung cancer has been reported. There are few data in other
Asian populations. We investigated this I462V polymorphism using DNA
from 214 incident cases of lung cancer and 669 controls in a
prospective cohort study of 18,244 middle-aged and older men in
Shanghai, China. The valine allele frequency was 0.138 among the
control population. The I462V genotype was not appreciably associated
with lung cancer risk overall. There was some suggestion that having at
least one valine allele might be related to increased risk of lung
cancer among smokers of <20 cigarettes/day (odds ratio, 1.72; 95%
confidence interval, 0.82–3.62), particularly among those with
homozygous deletion of GSTM1 (odds ratio, 2.80; 95%
confidence interval, 1.07–7.33), which is involved in the
detoxification of activated tobacco carcinogens. In this Chinese
cohort, with CYP1A1 valine allele frequency intermediate
between Japanese and Caucasian populations, the I462V polymorphism is
not related to lung cancer overall, but it might play a role at lower
levels of cigarette smoking among subjects with impaired carcinogen
detoxification as assessed by the GSTM1 -null genotype.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 11008920</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Analysis. Health state ; Benzo(a)pyrene - metabolism ; Biological and medical sciences ; Carcinogens - metabolism ; China - epidemiology ; Cohort Studies ; Cytochrome P-450 Enzyme System - genetics ; Epidemiology ; General aspects ; Glutathione Transferase - genetics ; Humans ; Inactivation, Metabolic ; Logistic Models ; Lung Neoplasms - enzymology ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Pneumology ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Smoking - genetics ; Smoking - metabolism ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2000-09, Vol.9 (9), p.987-991</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1507143$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11008920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LONDON, Stephanie J</creatorcontrib><creatorcontrib>YUAN, Jian-Min</creatorcontrib><creatorcontrib>COETZEE, Gerhard A</creatorcontrib><creatorcontrib>GAO, Yu-Tang</creatorcontrib><creatorcontrib>ROSS, Ronald K</creatorcontrib><creatorcontrib>YU, Mimi C</creatorcontrib><title>CYP1A1 I462V Genetic Polymorphism and Lung Cancer Risk in a Cohort of Men in Shanghai, China</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Cytochrome P450 (CYP) CYP1A1 activates tobacco-related
carcinogens. A point mutation at codon 462 in exon 7 of
CYP1A1 results in a substitution of isoleucine by valine
near the heme binding site. This mutation is rare in Caucasians but
common in Japanese populations, in which association with increased
risk of lung cancer has been reported. There are few data in other
Asian populations. We investigated this I462V polymorphism using DNA
from 214 incident cases of lung cancer and 669 controls in a
prospective cohort study of 18,244 middle-aged and older men in
Shanghai, China. The valine allele frequency was 0.138 among the
control population. The I462V genotype was not appreciably associated
with lung cancer risk overall. There was some suggestion that having at
least one valine allele might be related to increased risk of lung
cancer among smokers of <20 cigarettes/day (odds ratio, 1.72; 95%
confidence interval, 0.82–3.62), particularly among those with
homozygous deletion of GSTM1 (odds ratio, 2.80; 95%
confidence interval, 1.07–7.33), which is involved in the
detoxification of activated tobacco carcinogens. In this Chinese
cohort, with CYP1A1 valine allele frequency intermediate
between Japanese and Caucasian populations, the I462V polymorphism is
not related to lung cancer overall, but it might play a role at lower
levels of cigarette smoking among subjects with impaired carcinogen
detoxification as assessed by the GSTM1 -null genotype.</description><subject>Analysis. Health state</subject><subject>Benzo(a)pyrene - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carcinogens - metabolism</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Inactivation, Metabolic</subject><subject>Logistic Models</subject><subject>Lung Neoplasms - enzymology</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pneumology</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Smoking - genetics</subject><subject>Smoking - metabolism</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpFj11LwzAUhosobk7_guRCvLJw0jZtcjmKzsHE4RcIQknTkyW6piPZkP17OzeRc_EeXh5eeI6iIWUpj4uCseP-B8ZiIXI2iM5C-ASAQjB2Gg0oBeAigWH0Ub7P6ZiSaZYnb2SCDtdWkXm33LadXxkbWiJdQ2YbtyCldAo9ebLhi1hHJCk70_k16TR5QLerno10CyPtDSmNdfI8OtFyGfDikKPo9e72pbyPZ4-TaTmexSbJi3XMa9QKBNQ5powJofOMokoYKN4kMhFa5JhnWDOtE8AGaqW4yFLgEjTNMp6Oosv97mpTt9hUK29b6bfVn2YPXB0AGZRcat-b2PDPMSholvbY9R4zdmG-rcdK_Sp7DCi9MpXYHS_SH4bzZz4</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>LONDON, Stephanie J</creator><creator>YUAN, Jian-Min</creator><creator>COETZEE, Gerhard A</creator><creator>GAO, Yu-Tang</creator><creator>ROSS, Ronald K</creator><creator>YU, Mimi C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20000901</creationdate><title>CYP1A1 I462V Genetic Polymorphism and Lung Cancer Risk in a Cohort of Men in Shanghai, China</title><author>LONDON, Stephanie J ; YUAN, Jian-Min ; COETZEE, Gerhard A ; GAO, Yu-Tang ; ROSS, Ronald K ; YU, Mimi C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-8befc090b6e35599f641ec250c8d2a29f96e64eb5ff20ed0bcc894308a0f14483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis. Health state</topic><topic>Benzo(a)pyrene - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carcinogens - metabolism</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Cytochrome P-450 Enzyme System - genetics</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Inactivation, Metabolic</topic><topic>Logistic Models</topic><topic>Lung Neoplasms - enzymology</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Pneumology</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Smoking - genetics</topic><topic>Smoking - metabolism</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LONDON, Stephanie J</creatorcontrib><creatorcontrib>YUAN, Jian-Min</creatorcontrib><creatorcontrib>COETZEE, Gerhard A</creatorcontrib><creatorcontrib>GAO, Yu-Tang</creatorcontrib><creatorcontrib>ROSS, Ronald K</creatorcontrib><creatorcontrib>YU, Mimi C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LONDON, Stephanie J</au><au>YUAN, Jian-Min</au><au>COETZEE, Gerhard A</au><au>GAO, Yu-Tang</au><au>ROSS, Ronald K</au><au>YU, Mimi C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CYP1A1 I462V Genetic Polymorphism and Lung Cancer Risk in a Cohort of Men in Shanghai, China</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>9</volume><issue>9</issue><spage>987</spage><epage>991</epage><pages>987-991</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Cytochrome P450 (CYP) CYP1A1 activates tobacco-related
carcinogens. A point mutation at codon 462 in exon 7 of
CYP1A1 results in a substitution of isoleucine by valine
near the heme binding site. This mutation is rare in Caucasians but
common in Japanese populations, in which association with increased
risk of lung cancer has been reported. There are few data in other
Asian populations. We investigated this I462V polymorphism using DNA
from 214 incident cases of lung cancer and 669 controls in a
prospective cohort study of 18,244 middle-aged and older men in
Shanghai, China. The valine allele frequency was 0.138 among the
control population. The I462V genotype was not appreciably associated
with lung cancer risk overall. There was some suggestion that having at
least one valine allele might be related to increased risk of lung
cancer among smokers of <20 cigarettes/day (odds ratio, 1.72; 95%
confidence interval, 0.82–3.62), particularly among those with
homozygous deletion of GSTM1 (odds ratio, 2.80; 95%
confidence interval, 1.07–7.33), which is involved in the
detoxification of activated tobacco carcinogens. In this Chinese
cohort, with CYP1A1 valine allele frequency intermediate
between Japanese and Caucasian populations, the I462V polymorphism is
not related to lung cancer overall, but it might play a role at lower
levels of cigarette smoking among subjects with impaired carcinogen
detoxification as assessed by the GSTM1 -null genotype.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>11008920</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2000-09, Vol.9 (9), p.987-991 |
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| source | EZB Electronic Journals Library |
| subjects | Analysis. Health state Benzo(a)pyrene - metabolism Biological and medical sciences Carcinogens - metabolism China - epidemiology Cohort Studies Cytochrome P-450 Enzyme System - genetics Epidemiology General aspects Glutathione Transferase - genetics Humans Inactivation, Metabolic Logistic Models Lung Neoplasms - enzymology Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Medical sciences Middle Aged Odds Ratio Pneumology Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Smoking - genetics Smoking - metabolism Tumors of the respiratory system and mediastinum |
| title | CYP1A1 I462V Genetic Polymorphism and Lung Cancer Risk in a Cohort of Men in Shanghai, China |
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