Optical Monitoring of Neuronal Activity During Spontaneous Sharp Waves in Chronically Epileptic Human Neocortical Tissue

  1 Institut für Physiologie, Westfälische Wilhelms-Universität, 48149 Münster;   2 Max-Planck-Institut f. Biophysikalische Chemie, 37077 Göttingen; and   3 Epilepsiezentrum Bethel, 33617 Bielefeld, Germany Köhling, Rüdiger, Jörg-Michael Höhling, Heidrun Straub, Dieter Kuhlmann, Ulrich Kuhnt, Ingrid...

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Published in:Journal of neurophysiology 2000-10, Vol.84 (4), p.2161-2165
Main Authors: Kohling, Rudiger, Hohling, Jorg-Michael, Straub, Heidrun, Kuhlmann, Dieter, Kuhnt, Ulrich, Tuxhorn, Ingrid, Ebner, Alois, Wolf, Peter, Pannek, Heinz-Wolfgang, Gorji, Ali, Speckmann, Erwin-Josef
Format: Article
Language:English
Subjects:
Action Potentials
Chronic Disease
Dose-Response Relationship, Drug
Epilepsy - pathology
Epilepsy - physiopathology
Humans
In Vitro Techniques
Magnesium - administration & dosage
Magnesium - pharmacology
Neocortex - drug effects
Neocortex - pathology
Neocortex - physiopathology
Nerve Net - physiopathology
Neurons - physiology
Optics and Photonics
Periodicity
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Summary:  1 Institut für Physiologie, Westfälische Wilhelms-Universität, 48149 Münster;   2 Max-Planck-Institut f. Biophysikalische Chemie, 37077 Göttingen; and   3 Epilepsiezentrum Bethel, 33617 Bielefeld, Germany Köhling, Rüdiger, Jörg-Michael Höhling, Heidrun Straub, Dieter Kuhlmann, Ulrich Kuhnt, Ingrid Tuxhorn, Alois Ebner, Peter Wolf, Heinz-Wolfgang Pannek, Ali Gorji, and Erwin-Josef Speckmann. Optical Monitoring of Neuronal Activity During Spontaneous Sharp Waves in Chronically Epileptic Human Neocortical Tissue. J. Neurophysiol. 84: 2161-2165, 2000. Functional changes in neuronal circuitry reflected in spontaneously occurring synchronous sharp field potentials (SSFP) have been reported to occur in human brain suffering from chronic epileptogenicity but not in primary nonepileptic tissue from peritumoral resectates. Voltage sensitive dyes and fast imaging were used to visualize spontaneously occurring rhythmic depolarizations correlated to SSFP in chronically epileptic human neocortical slices obtained during epilepsy surgery. Localized and spatially inhomogeneous neuronal depolarizations were found to underlie spontaneous SSFP, which remained unchanged and spatially restricted to foci
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.2000.84.4.2161