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MECHANISMS OF SYNAPTIC VESICLE EXOCYTOSIS
Chemical synaptic transmission serves as the main form of cell to cell communication in the nervous system. Neurotransmitter release occurs through the process of regulated exocytosis, in which a synaptic vesicle releases its contents in response to an increase in calcium. The use of genetic, bioche...
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| Published in: | Annual review of cell and developmental biology 2000-01, Vol.16 (1), p.19-49 |
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| container_end_page | 49 |
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| container_title | Annual review of cell and developmental biology |
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| creator | Lin, Richard C Scheller, Richard H |
| description | Chemical synaptic transmission serves as the main form of cell to cell
communication in the nervous system. Neurotransmitter release occurs through
the process of regulated exocytosis, in which a synaptic vesicle releases its
contents in response to an increase in calcium. The use of genetic,
biochemical, structural, and functional studies has led to the identification
of factors important in the synaptic vesicle life cycle. Here we focus on the
prominent role of SNARE (soluble NSF attachment protein receptor) proteins
during membrane fusion and the regulation of SNARE function by Rab3a, nSec1,
and NSF. Many of the proteins important for transmitter release have homologs
involved in intracellular vesicle transport, and all forms of vesicle
trafficking share common basic principles. Finally, modifications to the
synaptic exocytosis pathway are very likely to underlie certain forms of
synaptic plasticity and therefore contribute to learning and memory. |
| doi_str_mv | 10.1146/annurev.cellbio.16.1.19 |
| format | article |
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communication in the nervous system. Neurotransmitter release occurs through
the process of regulated exocytosis, in which a synaptic vesicle releases its
contents in response to an increase in calcium. The use of genetic,
biochemical, structural, and functional studies has led to the identification
of factors important in the synaptic vesicle life cycle. Here we focus on the
prominent role of SNARE (soluble NSF attachment protein receptor) proteins
during membrane fusion and the regulation of SNARE function by Rab3a, nSec1,
and NSF. Many of the proteins important for transmitter release have homologs
involved in intracellular vesicle transport, and all forms of vesicle
trafficking share common basic principles. Finally, modifications to the
synaptic exocytosis pathway are very likely to underlie certain forms of
synaptic plasticity and therefore contribute to learning and memory.</description><identifier>ISSN: 1081-0706</identifier><identifier>EISSN: 1530-8995</identifier><identifier>DOI: 10.1146/annurev.cellbio.16.1.19</identifier><identifier>PMID: 11031229</identifier><identifier>CODEN: ARDBF8</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Animals ; Calcium - metabolism ; Calcium-Binding Proteins ; Carrier Proteins - metabolism ; Exocytosis - physiology ; Humans ; membrane fusion ; Membrane Fusion - physiology ; Membrane Glycoproteins - metabolism ; Membrane Proteins - metabolism ; Munc18 Proteins ; Nerve Tissue Proteins - metabolism ; Phosphorylation ; rab3A GTP-Binding Protein - metabolism ; Signal Transduction - physiology ; SNARE ; SNARE complex ; SNARE Proteins ; Synaptic Vesicles - metabolism ; Synaptic Vesicles - physiology ; Synaptotagmins ; syntaxin ; VAMP ; vesicle trafficking ; Vesicular Transport Proteins</subject><ispartof>Annual review of cell and developmental biology, 2000-01, Vol.16 (1), p.19-49</ispartof><rights>Copyright © 2000 by Annual Reviews. All rights reserved</rights><rights>Copyright Annual Reviews, Inc. 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a486t-3a6a6909cb7fa0c150cebc52e52ff24b2089ae2a2b76244fb016acb970bcf5703</citedby><cites>FETCH-LOGICAL-a486t-3a6a6909cb7fa0c150cebc52e52ff24b2089ae2a2b76244fb016acb970bcf5703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.cellbio.16.1.19?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.cellbio.16.1.19$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,78274,78379</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11031229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Richard C</creatorcontrib><creatorcontrib>Scheller, Richard H</creatorcontrib><title>MECHANISMS OF SYNAPTIC VESICLE EXOCYTOSIS</title><title>Annual review of cell and developmental biology</title><addtitle>Annu Rev Cell Dev Biol</addtitle><description>Chemical synaptic transmission serves as the main form of cell to cell
communication in the nervous system. Neurotransmitter release occurs through
the process of regulated exocytosis, in which a synaptic vesicle releases its
contents in response to an increase in calcium. The use of genetic,
biochemical, structural, and functional studies has led to the identification
of factors important in the synaptic vesicle life cycle. Here we focus on the
prominent role of SNARE (soluble NSF attachment protein receptor) proteins
during membrane fusion and the regulation of SNARE function by Rab3a, nSec1,
and NSF. Many of the proteins important for transmitter release have homologs
involved in intracellular vesicle transport, and all forms of vesicle
trafficking share common basic principles. Finally, modifications to the
synaptic exocytosis pathway are very likely to underlie certain forms of
synaptic plasticity and therefore contribute to learning and memory.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium-Binding Proteins</subject><subject>Carrier Proteins - metabolism</subject><subject>Exocytosis - physiology</subject><subject>Humans</subject><subject>membrane fusion</subject><subject>Membrane Fusion - physiology</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Membrane Proteins - metabolism</subject><subject>Munc18 Proteins</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Phosphorylation</subject><subject>rab3A GTP-Binding Protein - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>SNARE</subject><subject>SNARE complex</subject><subject>SNARE Proteins</subject><subject>Synaptic Vesicles - metabolism</subject><subject>Synaptic Vesicles - physiology</subject><subject>Synaptotagmins</subject><subject>syntaxin</subject><subject>VAMP</subject><subject>vesicle trafficking</subject><subject>Vesicular Transport Proteins</subject><issn>1081-0706</issn><issn>1530-8995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqNkMFKw0AQhhdRrFZfQYsHwUPizG6ymwUvJaQ2UFshVexp2Y0baGmbmm0U397UBgQvyhxmDt98zPyEXCL4iAG_1et1Xdl3P7fLpZmXPnIffZQH5ARDBl4kZXjYzBChBwJ4h5w6twAAyVh4TDqIwJBSeUJuHpJ42B-n2UPWmwx62Wzcf5ymce85ydJ4lPSSl0k8m06yNDsjR4VeOnve9i55GiTTeOiNJvdp3B95Ooj41mOaay5B5kYUGnIMIbcmD6kNaVHQwFCIpLZUUyM4DYLCAHKdGynA5EUogHXJ9d67qcq32rqtWs3d7k-9tmXtlKCMSYbyTxCFoE1hA179AhdlXa2bJxRFIXkgItFAYg_lVelcZQu1qeYrXX0qBLXLXLWZqzZzhVyh-r7jotXXZmVff_bakBvgbg_sDHrZOOb2w_3b_wW5i5I_</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Lin, Richard C</creator><creator>Scheller, Richard H</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>MECHANISMS OF SYNAPTIC VESICLE EXOCYTOSIS</title><author>Lin, Richard C ; 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communication in the nervous system. Neurotransmitter release occurs through
the process of regulated exocytosis, in which a synaptic vesicle releases its
contents in response to an increase in calcium. The use of genetic,
biochemical, structural, and functional studies has led to the identification
of factors important in the synaptic vesicle life cycle. Here we focus on the
prominent role of SNARE (soluble NSF attachment protein receptor) proteins
during membrane fusion and the regulation of SNARE function by Rab3a, nSec1,
and NSF. Many of the proteins important for transmitter release have homologs
involved in intracellular vesicle transport, and all forms of vesicle
trafficking share common basic principles. Finally, modifications to the
synaptic exocytosis pathway are very likely to underlie certain forms of
synaptic plasticity and therefore contribute to learning and memory.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>11031229</pmid><doi>10.1146/annurev.cellbio.16.1.19</doi><tpages>31</tpages></addata></record> |
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| identifier | ISSN: 1081-0706 |
| ispartof | Annual review of cell and developmental biology, 2000-01, Vol.16 (1), p.19-49 |
| issn | 1081-0706 1530-8995 |
| language | eng |
| recordid | cdi_pubmed_primary_11031229 |
| source | Annual Reviews Sciences archive collection |
| subjects | Animals Calcium - metabolism Calcium-Binding Proteins Carrier Proteins - metabolism Exocytosis - physiology Humans membrane fusion Membrane Fusion - physiology Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Munc18 Proteins Nerve Tissue Proteins - metabolism Phosphorylation rab3A GTP-Binding Protein - metabolism Signal Transduction - physiology SNARE SNARE complex SNARE Proteins Synaptic Vesicles - metabolism Synaptic Vesicles - physiology Synaptotagmins syntaxin VAMP vesicle trafficking Vesicular Transport Proteins |
| title | MECHANISMS OF SYNAPTIC VESICLE EXOCYTOSIS |
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