An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio : Implications for atherogenesis prevention

It is generally accepted that free-radical induced blood lipid peroxidation and especially peroxidized LDL play a central role in the pathogenesis of atherosclerosis and related cardiovascular disease. Moreover, recent research highlights the key contribution of apolipoprotein B (apo B) to atherogen...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2000-10, Vol.119 (1), p.41-47
Main Authors: Ramı́rez-Boscá, Ana, Soler, Alfonso, Carrión, Miguel A, Dı́az-Alperi, Joaquı́n, Bernd, August, Quintanilla, Cesar, Quintanilla Almagro, Eliseo, Miquel, Jaime
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohols
Antioxidant
Apolipoproteins A - metabolism
Apolipoproteins B - metabolism
Apolipoprptein B/A
Arteriosclerosis - prevention & control
Biological and medical sciences
Curcuma longa
Female
General pharmacology
Humans
Lipoproteins, HDL - metabolism
Lipoproteins, LDL - metabolism
Male
Medical sciences
Middle Aged
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Zingiberales - metabolism
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Summary:It is generally accepted that free-radical induced blood lipid peroxidation and especially peroxidized LDL play a central role in the pathogenesis of atherosclerosis and related cardiovascular disease. Moreover, recent research highlights the key contribution of apolipoprotein B (apo B) to atherogenesis as the main inductor of one of its earlier steps, i.e. macrophage prolipheration. This has led us to investigate the apo B response to a very effective phenolic lipid-antioxidant, namely an hydroalcoholic extract of Curcuma longa, which according to our previous work does not show any toxic effects and decreases the levels of blood lipid peroxides, oxidized lipoproteins and fibrinogen. The present study shows that a daily oral administration of the extract decreases significantly the LDL and apo B and increases the HDL and apo A of healthy subjects. This and recent data on the increased anti-atherogenic action of the physiological antioxidant tocopherol in the presence of phenolic co-antioxidants (which eliminate the tocopheroxyl radical), justifies planned clinical research to test the usefulness of the curcuma extract as a co-antioxidant complement to standard treatments to prevent or retard atherosclerosis.
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(00)00169-X