Primary cerebral non-Hodgkin's lymphoma: problems with diagnosis and development of a protocol for management

The prognosis for primary cerebral non-Hodgkin's lymphoma has improved markedly in the under-70 age group with the introduction of combined chemotherapy and radiotherapy. A review of our patients has revealed difficulty in obtaining definitive histology initially in 21% (9/43). We investigated...

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Bibliographic Details
Published in:British journal of neurosurgery 2000-08, Vol.14 (4), p.313-315
Main Author: Cartmill, R. Allibone, E. M. Bessell, P. O. Byrne, M.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Anti-Inflammatory Agents - therapeutic use
Brain Neoplasms - diagnosis
Brain Neoplasms - drug therapy
Chemotherapy
Clinical Protocols
Corticosteroids Idiosyncratic Response Management Protocol Primary Cerebral Lymphoma
Cortisone
Dexamethasone - therapeutic use
Female
Humans
Lymphoma
Lymphoma, Non-Hodgkin - diagnosis
Lymphoma, Non-Hodgkin - drug therapy
Male
Medical diagnosis
Middle Aged
Prospective Studies
Retrospective Studies
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Summary:The prognosis for primary cerebral non-Hodgkin's lymphoma has improved markedly in the under-70 age group with the introduction of combined chemotherapy and radiotherapy. A review of our patients has revealed difficulty in obtaining definitive histology initially in 21% (9/43). We investigated the role of corticosteroids in these patients and found an idiosyncratic response in that there was no significance either of the cumulative dose ( p >0.424) or the length of treatment ( p >0.453) with the observed regression of lymphoma with corticosteroids. In order to avoid indiscriminate corticosteroid administration we have formulated a management protocol the entry point for which is a patient with enhanced computered tomography appearances of primary cerebral lymphoma.
ISSN:0268-8697
1360-046X
DOI:10.1080/026886900417270