Inhaled budesonide inhibits OVA-induced airway narrowing, inflammation, and cys-LT synthesis in BN rats

Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada H2X 2P2 The objective of the present investigation was to examine the effects of an inhaled glucocorticoid, budesonide, on antigen-induced production of cysteinyl leukotrienes (cys-LTs) and pulmonary inflammatory cell infiltr...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2000-11, Vol.89 (5), p.1852-1858
Main Authors: Xu, Lijing, Olivenstein, Ronald, Martin, James G, Powell, William S
Format: Article
Language:English
Subjects:
Administration, Inhalation
Airway Resistance - drug effects
Airway Resistance - immunology
Animals
Asthma
Asthma - drug therapy
Asthma - immunology
Asthma - metabolism
Bile - metabolism
Biological and medical sciences
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
Bronchodilator Agents - pharmacology
Budesonide - pharmacology
Cysteine - metabolism
Drug therapy
Effects
Leukotriene E4 - analogs & derivatives
Leukotriene E4 - biosynthesis
Macrophages, Alveolar - immunology
Macrophages, Alveolar - metabolism
Male
Medical sciences
Ovalbumin - immunology
Pharmacology. Drug treatments
Rats
Rats, Inbred BN
Respiratory system
Rodents
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Summary:Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada H2X 2P2 The objective of the present investigation was to examine the effects of an inhaled glucocorticoid, budesonide, on antigen-induced production of cysteinyl leukotrienes (cys-LTs) and pulmonary inflammatory cell infiltration in the Brown Norway rat, an animal model of asthma. Two weeks after sensitization to ovalbumin, rats were treated with budesonide (2.5 mg/kg) 18 and 1 h before challenge with antigen. Budesonide abolished the late response to ovalbumin ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2000.89.5.1852