The physiopathological significance of ceruloplasmin: A possible therapeutic approach

This article reviews and comments on the physiological roles of ceruloplasmin (Cp). We show that, in addition to its ascertained involvement in iron homeostasis, the protein, by virtue of its unique structure among multicopper oxidases, is likely involved in other processes of both an enzymatic and...

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Bibliographic Details
Published in:Biochemical pharmacology 2000-12, Vol.60 (12), p.1735-1741
Main Authors: Floris, Giovanni, Medda, Rosaria, Padiglia, Alessandra, Musci, Giovanni
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
biogenic amines
Biological and medical sciences
ceruloplasmin
Ceruloplasmin - metabolism
Ceruloplasmin - physiology
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Homeostasis
Humans
iron
Iron - metabolism
neurodiseases
Oxidation-Reduction
Oxidopamine - metabolism
Oxidoreductases
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Summary:This article reviews and comments on the physiological roles of ceruloplasmin (Cp). We show that, in addition to its ascertained involvement in iron homeostasis, the protein, by virtue of its unique structure among multicopper oxidases, is likely involved in other processes of both an enzymatic and a nonenzymatic nature. In particular, based on the analysis of the kinetic parameters, on the one hand, and of the side-products of the oxidation, on the other, we propose that the long-recognized ability of Cp to interact with and oxidize non-iron substrates may be of physiological relevance. The striking example of 6-hydroxydopamine oxidation is presented, where we show that the catalytic action is carried out readily under physiological conditions, without release of potentially toxic oxygen intermediates.
ISSN:0006-2952
1873-2968
DOI:10.1016/S0006-2952(00)00399-3