Treatment of adult Still's disease with dexamethasone, an alternative to prednisolone

We successfully treated three cases of adult Still's disease (ASD) with dexamethasone. High dose prednisolone, which was initially used to treat these patients, failed to remit the disease in all cases. Although they were resistant to prednisolone, all these patients had remarkable improvements...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 2000, Vol.29 (6), p.396-398
Main Author: Ryuichi Koizumi, Yoshito Tsukada, Hiroshi Ideura, Kazue Ueki, Akira Maezawa, Yoshihisa Nojima
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Dexamethasone - therapeutic use
Drug Resistance
Female
Glucocorticoids - therapeutic use
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Prednisolone - therapeutic use
Retreatment
Still's Disease, Adult-Onset - drug therapy
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Summary:We successfully treated three cases of adult Still's disease (ASD) with dexamethasone. High dose prednisolone, which was initially used to treat these patients, failed to remit the disease in all cases. Although they were resistant to prednisolone, all these patients had remarkable improvements in clinical and laboratory findings after switching to an equivalent dose of dexamethasone. We propose using dexamethasone as an alternative for treating ASD before adding immunosuppressants or disease modifying anti-rheumatic drugs (DMARD), when prednisolone therapy does not suppress disease activity sufficiently.
ISSN:0300-9742
1502-7732
DOI:10.1080/030097400447624