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Serum Organochlorine Levels and Breast Cancer: A Nested Case-Control Study of Norwegian Women
This study investigated the potential association between organochlorine exposure and breast cancer using stored sera collected from 1973 through 1991 from the Janus Serum Bank in Norway. Breast cancer cases were ascertained prospectively from among 25,431 female serum bank donors. A total of 150 co...
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Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-12, Vol.9 (12), p.1357-1367 |
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Main Authors: | , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | This
study investigated the potential association between organochlorine
exposure and breast cancer using stored sera collected from 1973
through 1991 from the Janus Serum Bank in Norway. Breast cancer
cases were ascertained prospectively from among 25,431 female serum
bank donors. A total of 150 controls were matched to cases by birth
dates and dates of sample collection. One g of serum per subject was
analyzed for a total of 71 organochlorine compounds. For 6 pesticides[
B- hexachlorocyclohexane, heptachlor epoxide,
oxychlordane, trans -nonachlor, p ,
p ′-1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene,
and p ,
p ′-2,2-bis( p -chlorophenyl)-1,1,1-trichloroethane]
and 26 individual polychlorinated biphenyl (PCB) congeners there were>
90% of samples over the limit of detection. There was no
evidence for higher mean serum levels among cases for any of these
compounds, nor any trend of increasing risk associated with higher
quartiles of exposure. The remaining compounds (including dieldrin)
were analyzed with respect to the proportion of cancer cases and
controls having detectable levels; no positive associations were noted
in these analyses. Our study did not confirm the recent findings of a
Danish study of increased concentrations of dieldrin in the serum of
breast cancer cases. The evidence to date on the association between
serum organochlorines is not entirely consistent, but there is
accumulating evidence that serum levels of p ,
p ′-1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene
and total PCBs are not important predictors for breast cancer in the
general population. Studies to date have not been able to evaluate
whether exposure to highly estrogenic, short-lived PCB congeners
increases breast cancer risk, nor have they fully evaluated the risk
associated with organochlorine exposure in susceptible subgroups or at
levels above general population exposure, including women with
occupational exposure. |
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ISSN: | 1055-9965 1538-7755 |