Clodronate prevents prosthetic migration: A randomized radiostereometric study of 50 total knee patients

In a double-blind study, we randomized 50 patients to receive peroral clodronate medication or placebo from 3 weeks before until 6 months after a total knee replacement with a cemented NexGen implant. Migration of the tibial components was measured by radiostereometry at 1 year. Clodronate reduced p...

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Bibliographic Details
Published in:Acta orthopaedica 2000, Vol.71 (6), p.553-557
Main Authors: Hilding, Maria, Ryd, Leif, Toksvig-Larsen, Sören, Aspenberg, Per
Format: Article
Language:English
Subjects:
Aged
Analgesics, Non-Narcotic - therapeutic use
Biological and medical sciences
Bone Resorption
Clodronic Acid - therapeutic use
Double-Blind Method
Humans
Knee Prosthesis
Medical sciences
Middle Aged
Orthopedic surgery
Prosthesis Failure
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:In a double-blind study, we randomized 50 patients to receive peroral clodronate medication or placebo from 3 weeks before until 6 months after a total knee replacement with a cemented NexGen implant. Migration of the tibial components was measured by radiostereometry at 1 year. Clodronate reduced prosthetic migration, as measured by maximum total point motion, from 0.40 mm to 0.29 mm (p = 0.01). This confirms that the early postoperative migration is related to bone resorption and thus the biology of the bone bed. Since early migration is related to late loosening, 6 months of clodronate medication might reduce the risk of loosening.
ISSN:1745-3674
0001-6470
1745-3682
DOI:10.1080/000164700317362163