Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat

Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706 Long-term facilitation (LTF) is a prolonged, serotonin-dependent augmentation of respiratory motor output following episodic hypoxia. Previous observations lead us to hypothesize that LTF is subject to genetic i...

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Bibliographic Details
Published in:Physiological genomics 2001-01, Vol.4 (3), p.175-181
Main Authors: FULLER, D. D, BAKER, T. L, BEHAN, M, MITCHELL, G. S
Format: Article
Language:English
Subjects:
Animals
Blood Gas Analysis
Female
Hypoglossal Nerve - chemistry
Hypoglossal Nerve - physiology
Hypoxia - physiopathology
Immunohistochemistry
In Vitro Techniques
Male
Motor Neurons - physiology
Phrenic Nerve - physiology
Rats
Rats, Sprague-Dawley
Respiratory Physiological Phenomena
Serotonin - analysis
Species Specificity
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Summary:Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706 Long-term facilitation (LTF) is a prolonged, serotonin-dependent augmentation of respiratory motor output following episodic hypoxia. Previous observations lead us to hypothesize that LTF is subject to genetic influences and, as a result, differs between Sprague-Dawley (SD) rats from two vendors, Harlan (H) and Charles River Laboratories/Sasco (CRL/S). Using a blinded experimental design, we recorded integrated phrenic ( Phr) and hypoglossal neurograms in anesthetized, vagotomized, paralyzed, and ventilated rats. At 60 min following three 5-min hypoxic episodes (Pa O 2 = 40 ± 1 Torr; 5-min hyperoxic intervals), Phr was elevated from baseline in both SD substrains (i.e., LTF; P < 0.05). Conversely, hypoglossal LTF was present in CRL/S but not H rats ( P < 0.05 between substrains). Serotonin immunoreactivity within the hypoglossal nucleus was not different between H and CRL/S rats. We conclude that the expression of hypoglossal LTF differs between SD rat substrains, indicating a difference in their genetic predisposition to neural plasticity. respiratory control; plasticity; genetics
ISSN:1094-8341
1531-2267
DOI:10.1152/physiolgenomics.2001.4.3.175