The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin

Two-stage carcinogenesis experiments on mouse skin (female ICR/Ha Swiss mice) were done by initiating mice at three age levels (6, 44, and 56 weeks) and promoting after a 2-week interval. In another series, mice were initiated at age 6 weeks, and three time intervals (2, 36, and 56 weeks) were used...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1975-03, Vol.35 (3), p.502
Main Authors: Van Duuren, B L, Sivak, A, Katz, C, Seidman, I, Melchionne, S
Format: Article
Language:English
Subjects:
Aging
Alcohols - administration & dosage
Animals
Benz(a)Anthracenes - administration & dosage
Carcinogens - administration & dosage
Diterpenes - administration & dosage
Female
Mice
Mice, Inbred ICR
Neoplasms, Experimental - chemically induced
Skin Neoplasms - chemically induced
Time Factors
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Summary:Two-stage carcinogenesis experiments on mouse skin (female ICR/Ha Swiss mice) were done by initiating mice at three age levels (6, 44, and 56 weeks) and promoting after a 2-week interval. In another series, mice were initiated at age 6 weeks, and three time intervals (2, 36, and 56 weeks) were used between initiation and promotion. The initiating agent was 7, 12-dimethylbenz(a)anthracene and the promoting agent was phorbol myristate acetate in all experiments. The results showed a general decrease in tumor production with increasing age at the time of promotion. However, the initiating effect persisted even when the interval between initiation and promotion was 56 weeks.
ISSN:0008-5472