Role of leukocytes in uterine hypoperfusion and fetal growth retardation induced by ischemia-reperfusion

1  Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582; and 2  Department of Clinical Research, National Ohkura Hospital, Tokyo 157-0063, Japan We investigated leukocyte involvement in uterine hypoperfusion and intrauterine fetal growth retardation (IUGR) indu...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-03, Vol.280 (3), p.H1215-H1221
Main Authors: Miyakoshi, Kei, Ishimoto, Hitoshi, Nishimura, Osamu, Tanigaki, Shinji, Tanaka, Mamoru, Miyazaki, Toyohiko, Natori, Michiya, Yoshimura, Yasunori
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - pharmacology
CD18 Antigens - immunology
Female
Fetal Growth Retardation - immunology
Fetal Growth Retardation - pathology
Fetal Growth Retardation - physiopathology
Fetal Weight
Leukocytes - physiology
Lymphocyte Function-Associated Antigen-1 - immunology
Organ Size
Placenta - blood supply
Placenta - immunology
Placenta - pathology
Pregnancy
Rats
Reperfusion Injury - immunology
Reperfusion Injury - pathology
Reperfusion Injury - physiopathology
Uterus - blood supply
Uterus - immunology
Uterus - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1  Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582; and 2  Department of Clinical Research, National Ohkura Hospital, Tokyo 157-0063, Japan We investigated leukocyte involvement in uterine hypoperfusion and intrauterine fetal growth retardation (IUGR) induced by ischemia-reperfusion (I/R) in Sprague-Dawley rats. On day 17  of gestation, leukocyte accumulation in the uterus and placenta subjected to 30 min of ischemia, followed by reperfusion, was assessed by measuring myeloperoxidase (MPO) activity. Uterine MPO activity was significantly higher after 1 h of reperfusion than it was before ischemia ( P
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.2001.280.3.h1215