Abnormal neurovascular control during exercise is linked to heart failure severity

• Published in: American journal of physiology. Heart and circulatory physiology 2001-03, Vol.280 (3), p.H1286-H1292
• Main Authors: Negrao, Carlos Eduardo, Rondon, Maria Urbana P. Brandao, Tinucci, Tais, Alves, Maria Janieire N, Roveda, Fabiana, Braga, Ana Maria W, Reis, Soraya F, Nastari, Luciano, Barretto, Antonio Carlos P, Krieger, Eduardo M, Middlekauff, Holly R
• Format: Article
• Language: English
• Subjects: Adult; Arteries - innervation; Arteries - physiology; Female; Forearm - blood supply; Hand Strength; Heart Failure - physiopathology; Humans; Male; Physical Exertion - physiology; Regional Blood Flow - physiology; Sympathetic Nervous System - physiopathology; Vascular Resistance - physiology
• ISSN: 0363-6135; 1522-1539
• DOI: 10.1152/ajpheart.2001.280.3.h1286

Unit of 1  Cardiovascular Rehabilitation and Exercise Physiology, 2  Hypertension, and 4  General Clinic of Cardiopathies, 3  School of Physical Education and Sports, InCor-Heart Institute, University of São Paulo Medical School, São Paulo, CEP 05403-000, Brazil; and 5  Department of Cardiology, University of California Medical School, Los Angeles, California 90095 The purpose of this study was to determine if abnormalities of sympathetic neural and vascular control are present in mild and/or severe heart failure (HF) and to determine the underlying afferent mechanisms. Patients with severe HF, mild HF, and age-matched controls were studied. Muscle sympathetic nerve activity (MSNA) and forearm vascular resistance (FVR) in the nonexercising arm were measured during mild and moderate static handgrip. MSNA during moderate handgrip was higher at baseline and throughout exercise in severe HF vs. mild HF (peak MSNA 67 ± 3 vs. 54 ± 3 bursts/min, P