Central nervous system vasculitis as a complication of refractory dermatomyositis

We describe a 47-year-old woman with refractory dermatomyositis (DM) who developed progressive cognitive dysfunction. Magnetic resonance imaging showed a large cerebral infarction, and the diagnosis of central nervous system (CNS) vasculitis was confirmed by both angiogram and brain biopsy. Her DM a...

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Bibliographic Details
Published in:Journal of rheumatology 2001-01, Vol.28 (1), p.207-211
Main Authors: REGAN, Michael, HAQUE, Uzma, POMPER, Martin, PARDO, Carlos, STONE, John
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - blood supply
Brain - pathology
Cerebral Angiography
Cerebral Infarction - pathology
Cyclophosphamide - therapeutic use
Dermatomyositis - complications
Dermatomyositis - drug therapy
Dermatomyositis - pathology
Female
Humans
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Vasculitis, Central Nervous System - drug therapy
Vasculitis, Central Nervous System - etiology
Vasculitis, Central Nervous System - pathology
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Summary:We describe a 47-year-old woman with refractory dermatomyositis (DM) who developed progressive cognitive dysfunction. Magnetic resonance imaging showed a large cerebral infarction, and the diagnosis of central nervous system (CNS) vasculitis was confirmed by both angiogram and brain biopsy. Her DM and CNS vasculitis responded promptly to the institution of daily cyclophosphamide, and her previously refractory disease entered remission.
ISSN:0315-162X
1499-2752