Spinal teratoma: is there a place for adjuvant treatment? Two cases and a review of the literature

• Published in: British journal of neurosurgery 2000-10, Vol.14 (5), p.482-488
• Main Author: Allsopp, S. Sgouros, P. Barber, A. R.Walsh, G.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Case studies; Conus; Female; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neurology; Radiology; Radiotherapy Spinal Teratoma Surgery; Radiotherapy, Adjuvant; Spinal Neoplasms - radiotherapy; Spinal Neoplasms - surgery; Spine; Surgery; Teratoma - pathology; Teratoma - radiotherapy; Teratoma - surgery; Treatment Outcome; Tumors; Tumors of the nervous system. Phacomatoses
• ISSN: 0268-8697; 1360-046X
• DOI: 10.1080/02688690050175364

Spinal teratomas are rare intradural spinal tumours, commonly of benign histological profile. The main treatment remains surgical excision which often is incomplete as the tumour is frequently intimately related to surrounding nerve roots and adjacent spinal cord. The value of adjuvant treatment in the form of radiotherapy has not been clearly identified. We report two patients with spinal teratomas in the lower thoracic and conus region, who were treated with surgical excision and did not receive radiotherapy. One of the tumours recurred at 38 months following surgical excision and required a second operation.We review in addition another 20 patients reported in the literature with such tumours.With a mean follow-up of 25 months a local recurrence rate of 10% was observed, the same in both total and subtotal excision groups. No deaths were reported. Analysis of cumulative survival from surgery to treatment failure demonstrated that recurrence occurs late, verifying a slow biological progression of this tumour type. Although no reliable information of the effect of radiotherapy can be obtained, it is difficult to see how radiotherapy could have an impact on such a slow growing tumour. Initial treatment of choice remains surgical excision. If the teratoma shows any malignant histological features or germ cell elements radiotherapy should be employed after surgical excision, even if apparently totally excised. In the presence of benign histology it would seem appropriate to avoid radiotherapy after initial surgery. In case of tumour recurrence or progression to explore the possibility of further surgery first, before considering radiotherapy which even then may have doubtful efficacy.