Neoangiogenesis in squamous cell carcinoma of the larynx - biological and prognostic associations

Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in t...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2001, Vol.197 (1), p.1
Main Authors: Sion-Vardy, N, Fliss, D M, Prinsloo, I, Shoham-Vardi, I, Benharroch, D
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - blood supply
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - therapy
Endothelium, Vascular - chemistry
Endothelium, Vascular - pathology
Factor VIII - analysis
Female
Follow-Up Studies
Humans
Laryngeal Neoplasms - blood supply
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - therapy
Lymphatic Metastasis
Male
Microcirculation
Middle Aged
Neovascularization, Pathologic - pathology
Platelet Endothelial Cell Adhesion Molecule-1
Prognosis
Radiotherapy, Adjuvant
Survival Rate
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor angiogenesis has been related to tumor growth and an increased probability of metastatic spread. Previous studies have led to conflicting views regarding the prognostic significance of angiogenesis in squamous cell carcinoma of the head and neck. To evaluate the role of tumor angiogenesis in the biology of squamous cell carcinoma of the larynx, we quantified the microvascular network in 59 primary laryngeal carcinomas and looked for an association with outcome. Microvessels were stained immunohistochemically using antibodies for factor VIII-related antigen and the antibody JC70 (CD-31). In each case, microvessels were counted in three fields at x200 magnification, in areas of most intense neovascularization. We found a significantly higher number of microvessels in tumors showing deeper levels of invasion.
ISSN:0344-0338