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Role of ventilation strategy on perfluorochemical evaporation from the lungs
1 Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei; 2 Department of Pediatrics, Children's Medical Center, Veterans General Hospital-Taipei, Taipei 11217, Taiwan, Republic of China; 3 Department of Pediatrics, Padua University, Padua 35158, Italy; 4 D...
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Published in: | Journal of applied physiology (1985) 2001-04, Vol.90 (4), p.1365-1372 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | 1 Institute of Clinical Medicine, National Yang-Ming
University School of Medicine, Taipei; 2 Department of
Pediatrics, Children's Medical Center, Veterans General
Hospital-Taipei, Taipei 11217, Taiwan, Republic of China;
3 Department of Pediatrics, Padua University, Padua 35158, Italy; 4 Department of Neonatology, Children's
Hospital of Philadelphia, University of Pennsylvania School of
Medicine; and 5 Departments of Physiology and Pediatrics,
Temple University School of Medicine, Philadelphia,
Pennsylvania 19140
To study the effect of ventilation strategy on
perfluorochemical (PFC) elimination profile (evaporative loss profile;
E L ), 6 ml/kg of perflubron were instilled into anesthetized
normal rabbits. The strategy was to maintain minute ventilation
( E , in ml/min) in three groups:
E L (low-range E ,
208 ± 2), E M (midrange
E , 250 ± 9), and
E H (high-range E ,
293 ± 1) over 4 h. In three other groups,
respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with
a constant E and adjusted tidal volume. PFC content
in the expired gas was measured, and E L was calculated.
There was a significant E - and time-dependent effect
on E L. Initially, percent PFC saturation and loss rate decreased in the E H > E M > E L groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such that
E H |
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ISSN: | 8750-7587 1522-1601 |
DOI: | 10.1152/jappl.2001.90.4.1365 |