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Role of ventilation strategy on perfluorochemical evaporation from the lungs

1  Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei; 2  Department of Pediatrics, Children's Medical Center, Veterans General Hospital-Taipei, Taipei 11217, Taiwan, Republic of China; 3  Department of Pediatrics, Padua University, Padua 35158, Italy; 4  D...

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Published in:Journal of applied physiology (1985) 2001-04, Vol.90 (4), p.1365-1372
Main Authors: Jeng, Mei-Jy, Trevisanuto, Daniele, Weis, Carla M, Fox, William W, Cullen, Aaron B, Wolfson, Marla R, Shaffer, Thomas H
Format: Article
Language:English
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Summary:1  Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei; 2  Department of Pediatrics, Children's Medical Center, Veterans General Hospital-Taipei, Taipei 11217, Taiwan, Republic of China; 3  Department of Pediatrics, Padua University, Padua 35158, Italy; 4  Department of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine; and 5  Departments of Physiology and Pediatrics, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 To study the effect of ventilation strategy on perfluorochemical (PFC) elimination profile (evaporative loss profile; E L ), 6 ml/kg of perflubron were instilled into anesthetized normal rabbits. The strategy was to maintain minute ventilation ( E , in ml/min) in three groups: E L (low-range E , 208 ± 2), E M (midrange E , 250 ± 9), and E H (high-range E , 293 ± 1) over 4 h. In three other groups, respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with a constant E and adjusted tidal volume. PFC content in the expired gas was measured, and E L was calculated. There was a significant E - and time-dependent effect on E L. Initially, percent PFC saturation and loss rate decreased in the E H  >  E M  >  E L groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such that E H  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2001.90.4.1365