Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men

Divisions of 1  Endocrinology and Metabolism and 2  Gerontology and Geriatrics, Departments of Medicine, Johns Hopkins Bayview Medical Center and Johns Hopkins University School of Medicine and 3  Endocrinology Section, Laboratory of Clinical Investigation, Intramural Research Program, National Inst...

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Published in:American journal of physiology: endocrinology and metabolism 2001-04, Vol.280 (4), p.E616-E625
Main Authors: Gusenoff, Jeffrey A, Harman, S. Mitchell, Veldhuis, Johannes D, Jayme, Jocelyn J, St. Clair, Carol, Munzer, Thomas, Christmas, Colleen, O'Connor, Kieran G, Stevens, Thomas E, Bellantoni, Michele F, Pabst, Katherine, Blackman, Marc R
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - metabolism
Body Composition
Body Mass Index
Female
Human Growth Hormone - secretion
Humans
Hydrocortisone - secretion
Male
Multivariate Analysis
Reference Values
Regression Analysis
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Summary:Divisions of 1  Endocrinology and Metabolism and 2  Gerontology and Geriatrics, Departments of Medicine, Johns Hopkins Bayview Medical Center and Johns Hopkins University School of Medicine and 3  Endocrinology Section, Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224; and 4  Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 We studied 130 healthy aged women ( n  = 57) and men ( n  = 73), age 65-88 yr, with age-related reductions in insulin-like growth factor I and gonadal steroid levels to assess the interrelationships between cortisol and growth hormone (GH) secretion and whether these relationships differ by sex. Blood was sampled every 20   min from 8:00 PM to 8:00 AM; cortisol was measured by RIA and GH by immunoradiometric assay, followed by deconvolution analyses of hormone secretory parameters and assessment of approximate entropy (ApEn) and cross-ApEn. Cortisol mass/burst, cortisol production rate, and mean and integrated serum cortisol concentrations ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.2001.280.4.E616