Enhanced renal expression of preproendothelin mRNA during chronic angiotensin II hypertension

Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 The purpose of this study was to determine the role of endothelin in mediating the renal hemodynamic and arterial pressure changes obs...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-05, Vol.280 (5), p.1388-R1392
Main Authors: Alexander, Barbara T, Cockrell, Kathy L, Rinewalt, A. Nicole, Herrington, Jason N, Granger, Joey P
Format: Article
Language:English
Subjects:
Angiotensin II - administration & dosage
Angiotensin II - pharmacology
Animals
Blood Pressure - drug effects
Endothelin Receptor Antagonists
Endothelin-1
Endothelins - genetics
Gene Expression Regulation - physiology
Glomerular Filtration Rate
Hemodynamics - drug effects
Hemodynamics - physiology
Hypertension - chemically induced
Hypertension - physiopathology
Infusions, Intravenous
Kidney - metabolism
Kidney - physiopathology
Kidney Cortex - metabolism
Kidney Medulla - metabolism
Male
Protein Precursors - genetics
Pyrrolidines - pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Endothelin A
Renal Circulation - drug effects
Renal Circulation - physiology
RNA, Messenger - genetics
Transcription, Genetic - physiology
Urodynamics - drug effects
Urodynamics - physiology
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Summary:Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 The purpose of this study was to determine the role of endothelin in mediating the renal hemodynamic and arterial pressure changes observed during chronic ANG II-induced hypertension. ANG II (50 ng · kg 1 · min 1 ) was chronically infused into the jugular vein by miniosmotic pump for 2 wk in male Sprague-Dawley rats with and without endothelin type A (ET A )-receptor antagonist ABT-627 (5 mg · kg 1 · day 1 ) pretreatment. Arterial pressure increased in ANG II rats compared with control rats (149 ± 5 vs. 121 ± 6 mmHg, P  
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.2001.280.5.R1388