Effects of body temperature during exercise training on myocardial adaptations

• Published in: American journal of physiology. Heart and circulatory physiology 2001-05, Vol.280 (5), p.H2271-H2280
• Main Authors: Harris, M. Brennan, Starnes, Joseph W
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological - physiology; Animals; Antioxidants - metabolism; Body Temperature - physiology; Catalase - analysis; Crystallins - analysis; Electron Transport Complex IV - analysis; Glutathione Peroxidase - analysis; Heart - physiology; Heme Oxygenase (Decyclizing) - analysis; Heme Oxygenase-1; HSP70 Heat-Shock Proteins - analysis; HSP90 Heat-Shock Proteins - analysis; Male; Membrane Proteins - analysis; Muscle, Skeletal - chemistry; Muscle, Skeletal - metabolism; Myocardial Reperfusion Injury - physiopathology; Myocardium - chemistry; Myocardium - enzymology; Physical Conditioning, Animal - physiology; Rats; Rats, Sprague-Dawley; Stress, Physiological - physiopathology; Superoxide Dismutase - analysis
• ISSN: 0363-6135; 1522-1539
• DOI: 10.1152/ajpheart.2001.280.5.h2271

Cardiac Metabolism Laboratory, Department of Kinesiology, University of Texas, Austin, Texas 78712 This study determined the role of body temperature during chronic exercise on myocardial stress proteins and antioxidant enzymes as well as functional recovery after an ischemic insult. Male Sprague-Dawley rats were exercised for 3, 6, or 9 wk in a 23°C room (3WK, 6WK, and 9WK, respectively) or in a 4-8°C environment with wetted fur (3WKC, 6WKC, and 9WKC, respectively). The colder room prevented elevations in core temperature. During weeks 3-9 the animals ran 5 days/wk up a 6% grade at 20 m/min for 60 min. Myocardial heat shock protein 70 (HSP 70) increased 12.3-fold ( P