Diagnosis of concurrent hemoglobin H disease and heterozygous beta-thalassemia

Definitive diagnosis of concurrent hemoglobin (Hb) H disease and heterozygous beta-thalassemia cannot be made from Hb analysis alone, but necessitates genotype analysis and family study. Interactions between alpha- and beta-thalassemia must be considered when investigating moderate to severe hypochr...

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Bibliographic Details
Published in:Haematologica (Roma) 2001-04, Vol.86 (4), p.432
Main Authors: Ma, ES, Chan, AY, Au, WY, Yeung, YM, Chan, LC
Format: Article
Language:English
Subjects:
Adult
alpha-Thalassemia - complications
alpha-Thalassemia - diagnosis
alpha-Thalassemia - genetics
Anemia, Hypochromic - etiology
beta-Thalassemia - complications
beta-Thalassemia - diagnosis
beta-Thalassemia - genetics
DNA Mutational Analysis
Female
Globins - genetics
Heterozygote
Humans
Male
Mutation
Pregnancy
Pregnancy Complications, Hematologic
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Summary:Definitive diagnosis of concurrent hemoglobin (Hb) H disease and heterozygous beta-thalassemia cannot be made from Hb analysis alone, but necessitates genotype analysis and family study. Interactions between alpha- and beta-thalassemia must be considered when investigating moderate to severe hypochromic microcytic anemia of uncertain cause in adult patients from areas with a high prevalence of globin gene mutations.
ISSN:0390-6078
1592-8721