Less Adrenergic Response to Mental Task During Verapamil Compared to Amlodipine Treatment in Hypertensive Subjects

We compared the effects of amlodipine and verapamil slow release on autonomic responses to a 5-min mental arithmetic test (MST) in patients with mild to moderate hypertension. Twenty subjects received 8 weeks of verapamil slow release 240 mg or amlodipine 10 mg in a double-blind crossover design, bo...

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Bibliographic Details
Published in:Blood pressure 2001, Vol.10 (2), p.111-115
Main Author: Knut Sevre, Johan D. Lefrandt, Ivar Eide, Andries J. Smit, Morten Rostrup
Format: Article
Language:English
Subjects:
Adrenergic Agents - pharmacology
Adult
Aged
Amlodipine - administration & dosage
Amlodipine - pharmacology
Antihypertensive agents
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - pharmacology
Baroreflex - drug effects
Baroreflex Calcium Antagonists Catecholamines Hypertension Mental Stress
Biological and medical sciences
Blood Pressure - drug effects
Calcium Channel Blockers - administration & dosage
Calcium Channel Blockers - pharmacology
Cardiovascular system
Catecholamines - blood
Female
Heart Rate - drug effects
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Intelligence Tests
Male
Medical sciences
Middle Aged
Norepinephrine - blood
Pharmacology. Drug treatments
Stress, Psychological
Verapamil - administration & dosage
Verapamil - pharmacology
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Summary:We compared the effects of amlodipine and verapamil slow release on autonomic responses to a 5-min mental arithmetic test (MST) in patients with mild to moderate hypertension. Twenty subjects received 8 weeks of verapamil slow release 240 mg or amlodipine 10 mg in a double-blind crossover design, both after 4 weeks' placebo. Heart rate (HR) and blood pressure (BP) were continuously monitored. Venous plasma catecholamines were analysed by a radioenzymatic assay. Baroreflex sensitivity (BRS) was estimated with the transfer function technique. Calculations of the area under the curve (AUC) were used to estimate average HR, BP and catecholamine concentrations. The reactivity to MST was estimated as percent change from the basal AUC. A paired t
ISSN:0803-7051
1651-1999
DOI:10.1080/08037050152112096