Are women with acute myocardial infarction managed as well as men? Does it have consequences on in-hospital mortality? Analysis of an unselected cohort of 801 women and 1,718 men

• Published in: Acta Cardiologica 2001-06, Vol.56 (3), p.169-179
• Main Authors: Gevigney, Guy De, Mosnier, Stéphanie, Ecochard, René, Rabilloud, Muriel, Cao, Danièle, Excoffier, Sylvie, Cheneau, Edouard, Milon, Hugues, Delahaye, François
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Biological and medical sciences; Cardiology. Vascular system; Cohort Studies; Coronary heart disease; Female; gender; Heart; Hospital Mortality; Humans; Male; management; Medical sciences; Middle Aged; Multivariate Analysis; myocardial infarction; Myocardial Infarction - etiology; Myocardial Infarction - mortality; Myocardial Infarction - therapy; Outcome and Process Assessment (Health Care); Patient Admission; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Factors; Sex Factors; Survival Rate; Time Factors
• ISSN: 0001-5385; 0373-7934; 1784-973X
• DOI: 10.2143/AC.56.3.2005637

Objective - This study sought to compare characteristics and management of myocardial infarction in men and women, and whether a difference in management would translate into a difference in in-hospital mortality. Methods and results - Data were prospectively collected in 2,519 patients (801 women) admitted in all hospitals in three departments in the Rhône-Alpes region in France between September 1, 1993 and January 31, 1995.Women were older than men (76 vs. 64 years).The interval between symptom onset and initial medical intervention was longer in women than in men (median: 180 vs. 135 minutes), as was the interval between symptom onset and hospital admission (median: 315 vs. 255 minutes). After age-adjustment, women were less often smokers, and more often hypertensive or diabetic than men, location of infarction was more often anterior in women, as congestive heart failure at admission. In multivariate analysis, thrombolysis rate was not significantly different in both sexes, whereas noninvasive tests, coronary arteriography, percutaneous transluminal coronary angioplasty, and coronary artery bypass grafting were significantly less often performed in women than in men. Although in-hospital mortality was higher in women than in men (21% vs. 11%), this difference disappeared after age-adjustment (relative risk = 0.99). In multivariate analysis, gender was not an independent predictor of survival. Conclusions - Although in-hospital mortality after myocardial infarction was similar in both sexes, rates of diagnostic and therapeutic procedures were lower in women than in men. This raises the question of whether mortality would decrease in women if management were similar in both sexes.