Delayed-type hypersensitivity and humoral immunity modulation by dietary lipids in a murine model of pulmonary tumorigenesis induced by urethan

Mice fed on semisynthetic formulas containing 15% of corn oil (CO), cod fish liver oil (FO), oleic acid (O) or a mixture of 46% of palmitic and 50% of stearic acids (PS) were treated with urethan during 18 weeks for lung tumor induction. Delayed-type hypersensitivity (DTH) assay, hemagglutination as...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001-06, Vol.53 (2-3), p.181-186
Main Authors: PIEGARI, Mariana, SALVADOR, Ana Fabiola, MUNOZ, Sonia E, VALENTICH, Mirta A, EYNARD, Aldo R
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemically induced
Adenocarcinoma - immunology
Adenocarcinoma - pathology
Animals
Antibody Formation - drug effects
Biological and medical sciences
Carcinogens - toxicity
Dietary Fats, Unsaturated - administration & dosage
Dietary Fats, Unsaturated - analysis
Disease Models, Animal
Fatty Acids, Essential - administration & dosage
Fatty Acids, Essential - deficiency
Female
Hypersensitivity, Delayed
Immunity, Cellular - drug effects
Lung Neoplasms - chemically induced
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Male
Medical sciences
Mice
Mice, Inbred BALB C
Pneumology
Random Allocation
Tumors of the respiratory system and mediastinum
Urethane - toxicity
Weight Gain - drug effects
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Summary:Mice fed on semisynthetic formulas containing 15% of corn oil (CO), cod fish liver oil (FO), oleic acid (O) or a mixture of 46% of palmitic and 50% of stearic acids (PS) were treated with urethan during 18 weeks for lung tumor induction. Delayed-type hypersensitivity (DTH) assay, hemagglutination assay and the amount of lung nodes (alveolar adenocarcinomas) were recorded. Results showed significantly greater DTH in CO and FO with respect to O and PS feeding mice; the two last ones induced an essential fatty acid (EFA) deficiency (EFAD). In the O lot there was a non-significant diminution of the humoral response. EFAD animals exhibited a tendency to increase number of lung nodes in relation to CO and FO lots. Splenomegalia was recorded in FO lot. Confront between spleen weight and DTH showed a 72% correlation, suggesting an increase in cellular immunity as increasing unsaturation. It may be concluded that in this suitable model of tumorigenesis the manipulation of dietary lipids may be a strategy to modify the immune system response.
ISSN:0940-2993
1618-1433
DOI:10.1078/0940-2993-00174