Laser Doppler Measurement of Cochlear Blood Flow Changes During Conditioning Noise Exposure

Using laser Doppler flowmetry, cochlear blood flow was assessed in Mongolian gerbils exposed to noise. Anesthetized animals were surgically implanted with permanent electrodes and then exposed for 10 consecutive days (6 h on/18 h off) to an octave band noise centered at 4 kHz (85 dB SPL). The audito...

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Bibliographic Details
Published in:Acta oto-laryngologica 2001, Vol.121 (4), p.465-469
Main Author: Giuseppe Attanasio, Giuseppe Buongiorno, Federico Piccoli, Barbara Mafera, Aldo Cordier, Maurizio Barbara, Roberto Filipo
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animals
Auditory Threshold - physiology
Biological and medical sciences
Blood Flow Velocity - physiology
Cochlea - blood supply
Cochlea - physiopathology
Conditioning, Operant
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Ent, orbit
Evoked Potentials, Auditory, Brain Stem - physiology
Gerbillinae
Hearing Loss, Noise-Induced - diagnosis
Hearing Loss, Noise-Induced - etiology
Hearing Loss, Noise-Induced - physiopathology
Hypoxia - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Laser Doppler Flowmetry Mongolian Gerbil Noise-INDUCED Hearing Loss Resistance To Noise
Laser-Doppler Flowmetry - instrumentation
Medical sciences
Noise - adverse effects
Non tumoral diseases
Otorhinolaryngology. Stomatology
Severity of Illness Index
Ultrasonic investigative techniques
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Summary:Using laser Doppler flowmetry, cochlear blood flow was assessed in Mongolian gerbils exposed to noise. Anesthetized animals were surgically implanted with permanent electrodes and then exposed for 10 consecutive days (6 h on/18 h off) to an octave band noise centered at 4 kHz (85 dB SPL). The auditory brainstem responses and the blood flow in the basal turn of the cochlea were compared with those of gerbils not exposed to noise. The exposed animals developed an initial threshold shift, followed by a progressive reduction in threshold shift up to complete recovery at the end of the test. In the exposed animals, a reduction in the cochlear blood flow during the first 4 days of exposure was observed, which was then followed by a progressive increase up to the end of the test. The results of this study exclude a possible role of the microvasculature of the lateral cochlear wall in determining the resistance to 4 kHz frequency noise exposure.
ISSN:0001-6489
1651-2251
DOI:10.1080/00016480120524