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Structural adaptation of microvascular networks: functional roles of adaptive responses
1 Department of Physiology, Freie Universität Berlin, D-14195 Berlin; 2 Deutsches Herzzentrum Berlin, D-13353 Berlin, Germany; and 3 Department of Physiology, University of Arizona, Tucson, Arizona 85724 Terminal vascular beds continually adapt to changing demands. A theoretical model is used to...
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| Published in: | American journal of physiology. Heart and circulatory physiology 2001-09, Vol.281 (3), p.H1015-H1025 |
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| Language: | English |
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| container_end_page | H1025 |
| container_issue | 3 |
| container_start_page | H1015 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 281 |
| creator | Pries, A. R Reglin, B Secomb, T. W |
| description | 1 Department of Physiology, Freie Universität Berlin,
D-14195 Berlin; 2 Deutsches Herzzentrum Berlin, D-13353
Berlin, Germany; and 3 Department of Physiology, University
of Arizona, Tucson, Arizona 85724
Terminal vascular beds continually adapt to
changing demands. A theoretical model is used to simulate structural
diameter changes in response to hemodynamic and metabolic stimuli in
microvascular networks. Increased wall shear stress and decreased
intravascular pressure are assumed to stimulate diameter increase.
Intravascular partial pressure of oxygen (P O 2 )
is estimated for each segment. Decreasing P O 2
is assumed to generate a metabolic stimulus for diameter increase,
which acts locally, upstream via conduction along vessel walls, and
downstream via metabolite convection. By adjusting the sensitivities to
these stimuli, good agreement is achieved between predicted network
characteristics and experimental data from microvascular networks in
rat mesentery. Reduced pressure sensitivity leads to increased
capillary pressure with reduced viscous energy dissipation and little
change in tissue oxygenation. Dissipation decreases strongly with
decreased metabolic response. Below a threshold level of metabolic
response flow shifts to shorter pathways through the network, and
oxygen supply efficiency decreases sharply. In summary, the
distribution of vessel diameters generated by the simulated adaptive
process allows the network to meet the functional demands of tissue
while avoiding excessive viscous energy dissipation.
shear stress; pressure; conducted response; oxygen transport; mathematical modeling |
| doi_str_mv | 10.1152/ajpheart.2001.281.3.h1015 |
| format | article |
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D-14195 Berlin; 2 Deutsches Herzzentrum Berlin, D-13353
Berlin, Germany; and 3 Department of Physiology, University
of Arizona, Tucson, Arizona 85724
Terminal vascular beds continually adapt to
changing demands. A theoretical model is used to simulate structural
diameter changes in response to hemodynamic and metabolic stimuli in
microvascular networks. Increased wall shear stress and decreased
intravascular pressure are assumed to stimulate diameter increase.
Intravascular partial pressure of oxygen (P O 2 )
is estimated for each segment. Decreasing P O 2
is assumed to generate a metabolic stimulus for diameter increase,
which acts locally, upstream via conduction along vessel walls, and
downstream via metabolite convection. By adjusting the sensitivities to
these stimuli, good agreement is achieved between predicted network
characteristics and experimental data from microvascular networks in
rat mesentery. Reduced pressure sensitivity leads to increased
capillary pressure with reduced viscous energy dissipation and little
change in tissue oxygenation. Dissipation decreases strongly with
decreased metabolic response. Below a threshold level of metabolic
response flow shifts to shorter pathways through the network, and
oxygen supply efficiency decreases sharply. In summary, the
distribution of vessel diameters generated by the simulated adaptive
process allows the network to meet the functional demands of tissue
while avoiding excessive viscous energy dissipation.
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D-14195 Berlin; 2 Deutsches Herzzentrum Berlin, D-13353
Berlin, Germany; and 3 Department of Physiology, University
of Arizona, Tucson, Arizona 85724
Terminal vascular beds continually adapt to
changing demands. A theoretical model is used to simulate structural
diameter changes in response to hemodynamic and metabolic stimuli in
microvascular networks. Increased wall shear stress and decreased
intravascular pressure are assumed to stimulate diameter increase.
Intravascular partial pressure of oxygen (P O 2 )
is estimated for each segment. Decreasing P O 2
is assumed to generate a metabolic stimulus for diameter increase,
which acts locally, upstream via conduction along vessel walls, and
downstream via metabolite convection. By adjusting the sensitivities to
these stimuli, good agreement is achieved between predicted network
characteristics and experimental data from microvascular networks in
rat mesentery. Reduced pressure sensitivity leads to increased
capillary pressure with reduced viscous energy dissipation and little
change in tissue oxygenation. Dissipation decreases strongly with
decreased metabolic response. Below a threshold level of metabolic
response flow shifts to shorter pathways through the network, and
oxygen supply efficiency decreases sharply. In summary, the
distribution of vessel diameters generated by the simulated adaptive
process allows the network to meet the functional demands of tissue
while avoiding excessive viscous energy dissipation.
shear stress; pressure; conducted response; oxygen transport; mathematical modeling</description><subject>Adaptation, Physiological - physiology</subject><subject>Animals</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood Pressure - physiology</subject><subject>Blood Viscosity - physiology</subject><subject>Computer Simulation</subject><subject>Hemodynamics - physiology</subject><subject>Male</subject><subject>Mesentery - blood supply</subject><subject>Microcirculation - physiology</subject><subject>Models, Cardiovascular</subject><subject>Oxygen - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regional Blood Flow - physiology</subject><subject>Signal Transduction - physiology</subject><subject>Space life sciences</subject><subject>Stress, Mechanical</subject><subject>Vascular Patency - physiology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp1kE9P5CAYh4lxo7PqVzD14q2VtxQ61dNm4p9NTDyo8UgoBVtlSgWqzreX7oyre9gTycvz_F74IXQEOAOg-Yl4GlolXMhyjCHL55CRrAUMdAvN4n2eAiXVNpphwkjKgNBd9NP7J4wxLRnZQbsxBYqcsRl6uA1ulGF0wiSiEUMQobN9YnWy7KSzr8LL0QiX9Cq8WffsTxM99nJiouCsUX5i_5jdq0qc8oPtvfL76IcWxquDzbmH7i_O7xZX6fXN5e_Fr-tUxneGtClwVZS5VqXO6wpY3QDWVDbzqi51TaUQQBmhFchKwjRvalJQyoSkZF6oOdlDx-vcwdmXUfnAl52XyhjRKzt6XgJgggsWwWoNxl9575Tmg-uWwq04YD61yj9b5VOrPLbKCb-aWo3u4WbJWC9V82VuaozAyRpou8f2rXOKD-3Kd9bYx9W33H8iz_5vXIzG3Kn38Ff9ZvKh0eQDZV-eoQ</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Pries, A. R</creator><creator>Reglin, B</creator><creator>Secomb, T. W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Structural adaptation of microvascular networks: functional roles of adaptive responses</title><author>Pries, A. R ; Reglin, B ; Secomb, T. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-d409472fe7f2b916bd10f5cd89b7fb5caa1563591c9c15cd8db34556ac5384e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Animals</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood Pressure - physiology</topic><topic>Blood Viscosity - physiology</topic><topic>Computer Simulation</topic><topic>Hemodynamics - physiology</topic><topic>Male</topic><topic>Mesentery - blood supply</topic><topic>Microcirculation - physiology</topic><topic>Models, Cardiovascular</topic><topic>Oxygen - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional Blood Flow - physiology</topic><topic>Signal Transduction - physiology</topic><topic>Space life sciences</topic><topic>Stress, Mechanical</topic><topic>Vascular Patency - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pries, A. R</creatorcontrib><creatorcontrib>Reglin, B</creatorcontrib><creatorcontrib>Secomb, T. W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pries, A. R</au><au>Reglin, B</au><au>Secomb, T. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural adaptation of microvascular networks: functional roles of adaptive responses</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>281</volume><issue>3</issue><spage>H1015</spage><epage>H1025</epage><pages>H1015-H1025</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>1 Department of Physiology, Freie Universität Berlin,
D-14195 Berlin; 2 Deutsches Herzzentrum Berlin, D-13353
Berlin, Germany; and 3 Department of Physiology, University
of Arizona, Tucson, Arizona 85724
Terminal vascular beds continually adapt to
changing demands. A theoretical model is used to simulate structural
diameter changes in response to hemodynamic and metabolic stimuli in
microvascular networks. Increased wall shear stress and decreased
intravascular pressure are assumed to stimulate diameter increase.
Intravascular partial pressure of oxygen (P O 2 )
is estimated for each segment. Decreasing P O 2
is assumed to generate a metabolic stimulus for diameter increase,
which acts locally, upstream via conduction along vessel walls, and
downstream via metabolite convection. By adjusting the sensitivities to
these stimuli, good agreement is achieved between predicted network
characteristics and experimental data from microvascular networks in
rat mesentery. Reduced pressure sensitivity leads to increased
capillary pressure with reduced viscous energy dissipation and little
change in tissue oxygenation. Dissipation decreases strongly with
decreased metabolic response. Below a threshold level of metabolic
response flow shifts to shorter pathways through the network, and
oxygen supply efficiency decreases sharply. In summary, the
distribution of vessel diameters generated by the simulated adaptive
process allows the network to meet the functional demands of tissue
while avoiding excessive viscous energy dissipation.
shear stress; pressure; conducted response; oxygen transport; mathematical modeling</abstract><cop>United States</cop><pmid>11514266</pmid><doi>10.1152/ajpheart.2001.281.3.h1015</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2001-09, Vol.281 (3), p.H1015-H1025 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_pubmed_primary_11514266 |
| source | American Physiological Society Free |
| subjects | Adaptation, Physiological - physiology Animals Blood Flow Velocity - physiology Blood Pressure - physiology Blood Viscosity - physiology Computer Simulation Hemodynamics - physiology Male Mesentery - blood supply Microcirculation - physiology Models, Cardiovascular Oxygen - metabolism Rats Rats, Wistar Regional Blood Flow - physiology Signal Transduction - physiology Space life sciences Stress, Mechanical Vascular Patency - physiology |
| title | Structural adaptation of microvascular networks: functional roles of adaptive responses |
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