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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues

A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2001-09, Vol.11 (17), p.2229-2234
Main Authors: LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi
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Language:English
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Summary:A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00411-5