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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues
A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a...
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Published in: | Bioorganic & medicinal chemistry letters 2001-09, Vol.11 (17), p.2229-2234 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(01)00411-5 |