STRUCTURE-ACTIVITY RELATIONSHIPS OF APIO NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Ap...

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Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2001-04, Vol.20 (4-7), p.657-660
Main Authors: Jeong, Lak Shin, Moon, Hyung Ryong, Hong, Jun Hee, Yoo, Su Jeong, Choi, Won Jun, Kim, Hea Ok, Ahn, Hee Sung, Baek, Hye Woo, Chun, Moon Woo, Kim, Hee-Doo, Kim, Jeongmin, Choi, Jong-Ryoo
Format: Article
Language:English
Subjects:
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Dideoxynucleosides - chemical synthesis
Dideoxynucleosides - chemistry
Dideoxynucleosides - pharmacology
Microbial Sensitivity Tests
Structure-Activity Relationship
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Summary:Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100002344