CD4+ T-lymphocytopenia and systemic immune activation in patients with primary and secondary liver tumours

Using flow cytometry, we evaluated peripheral blood leucocyte subsets in 84 patients with primary and secondary liver cancer. The patients had significantly lower absolute (659+/-386 vs. 906+/-360 cells per microl, p=0.004) numbers of CD3+ CD4+, relative (9+/-5 vs. 12+/-4%, p=0.02) and absolute (154...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2001, Vol.61 (5), p.363-370
Main Authors: MELICHAR, B, TOUSKOVA, M, SOLICHOVA, D, KRALICKOVA, P, KOPECKY, O
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers - urine
CD3 Complex - analysis
Cd4+ T-LYMPHOCYTES Cd14+CD16+ Monocytes Liver Cancer Neopterin
CD4-Positive T-Lymphocytes - immunology
Female
Flow Cytometry
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunophenotyping
Liver Neoplasms - immunology
Liver Neoplasms - secondary
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lymphocyte Count
Lymphocytes - immunology
Lymphopenia - complications
Male
Medical sciences
Middle Aged
Neopterin - urine
Tumors
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Summary:Using flow cytometry, we evaluated peripheral blood leucocyte subsets in 84 patients with primary and secondary liver cancer. The patients had significantly lower absolute (659+/-386 vs. 906+/-360 cells per microl, p=0.004) numbers of CD3+ CD4+, relative (9+/-5 vs. 12+/-4%, p=0.02) and absolute (154+/-115 vs. 221+/-83 cells per microl, p=0.02) numbers of CD8+ CD28+, absolute numbers of CD3+ and relative and absolute numbers of CD19+. Relative and absolute numbers of CD3+ DR+, CD3+ CD69+ and CD14+ CD16+ cells were significantly elevated in patients compared to controls. The phenotype was similar in 54 patients exposed to chemotherapy compared to 30 untreated patients. Urinary neopterin, a marker of systemic immune activation, was significantly higher in patients with liver tumours compared to controls. A negative correlation was observed between urinary neopterin and the absolute numbers of CD3+ CD4+ (Spearman rank correlation coefficient, rs = -0.54, p
ISSN:0036-5513
1502-7686
DOI:10.1080/00365510116987