Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review

1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging...

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Bibliographic Details
Published in:Xenobiotica 2001, Vol.31 (8-9), p.599-617
Main Authors: Plumb, R. S., Dear, G. J., Mallett, D. N., Higton, D. M., Pleasance, S., Biddlecombe, R. A.
Format: Article
Language:English
Subjects:
Animals
Body Fluids - chemistry
Chromatography, High Pressure Liquid - instrumentation
Chromatography, High Pressure Liquid - methods
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Pharmaceutical Preparations - analysis
Robotics
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Summary:1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging technologies such as monolithic column chromatography and miniaturized chip-based systems are discussed.
ISSN:0049-8254
1366-5928
DOI:10.1080/00498250110060941